03810nam 22007335 450 991025394020332120200630163400.03-319-60907-610.1007/978-3-319-60907-2(CKB)3710000001631541(MiAaPQ)EBC4939344(DE-He213)978-3-319-60907-2(PPN)203851676(EXLCZ)99371000000163154120170804d2017 u| 0engurcnu||||||||rdacontentrdamediardacarrierExtracellular Matrix in Tumor Biology /edited by Rolf A. Brekken, Dwayne Stupack1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (115 pages)Biology of Extracellular Matrix,0887-32243-319-60906-8 Includes bibliographical references at the end of each chapters.1. The extracellular matrix of tumors: a focus on fibronectin and fibulin-5 -- 2. Internalization of collagen: an important matrix turnover pathway in cancer -- 3. Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression -- 4. Versican: Role in Cancer Tumorigenesis -- 5. Engineering advanced models of the glioblastoma microenvironment using biomaterials -- 6. Breaching and opening basement membrane barriers: the anchor cell leads the way.This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.Biology of Extracellular Matrix,0887-3224CancerResearchImmunologyMolecular biologyOncologyProteinsCytologyCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Immunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XOncologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33160Receptorshttps://scigraph.springernature.com/ontologies/product-market-codes/L14110Cell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008CancerResearch.Immunology.Molecular biology.Oncology.Proteins.Cytology.Cancer Research.Immunology.Molecular Medicine.Oncology.Receptors.Cell Biology.611.0182Brekken Rolf Aedthttp://id.loc.gov/vocabulary/relators/edtStupack Dwayneedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910253940203321Extracellular Matrix in Tumor Biology2056937UNINA