03285nam 22005413 450 991087685260332120231110230553.09781119738251111973825397811197376501119737656(CKB)5580000000490394(MiAaPQ)EBC7152584(Au-PeEL)EBL7152584(OCoLC)1354208310(OCoLC)1344159273(OCoLC-P)1344159273(CaSebORM)9781119737674(EXLCZ)99558000000049039420230111d2022 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierFlight Simulation Software Design, Development and TestingNewark :John Wiley & Sons, Incorporated,2022.©2023.1 online resource (0 pages)Aerospace 9781119737674 1119737672 "The use of simulation has become an integral activity in many branches of engineering, particularly in aerospace, where flight simulation is recognised as an essential part of training and checking for airline and military pilots. Less well known is the development of engineering flight simulators, mostly by aerospace companies, who have invested in simulation to support the design, development and testing of aircraft and systems, prior to manufacturing, reducing the development costs and increasing the design options. Nowadays, the components of a flight simulator are mostly commercial off-the-shelf items. The situation is very different for flight simulation software. Although it may be possible to connect simulator hardware to flight simulation games, the software may be proprietary, restricting access to the code and obscuring simplifications in the aircraft dynamics. Alternatively, simplified models of aircraft dynamics can be developed using modelling packages to visualise outputs. However, complex models produced by such methods are likely to run far too slow for interaction with a human pilot. In order to achieve real-time performance, a third option is to develop the software based on open software, where the simulator modules are compiled to executable code. While this approach is advocated in this textbook, it is not without its challenges. Producing software for a flight simulator, the developer is confronted with the breadth of engineering, covering aerodynamics, propulsion, mechanics, avionics and electronics and the depth of software covering mathematics, software engineering, distributed computing, real-time systems, computer graphics and control engineering"--Provided by publisher.Aerospace Flight Simulation SoftwareFlight simulatorsComputer programsAirplanesPilotingComputer simulationFlight simulatorsComputer programs.AirplanesPilotingComputer simulation.629.13252078Allerton David517113MiAaPQMiAaPQMiAaPQBOOK9910876852603321Flight Simulation Software4197916UNINA03900nam 22006735 450 991025393020332120200630052644.03-319-58518-510.1007/978-3-319-58518-5(CKB)3710000001393557(DE-He213)978-3-319-58518-5(MiAaPQ)EBC4869406(PPN)201472783(EXLCZ)99371000000139355720170531d2017 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierDecoding the Antibody Repertoire High Throughput Sequencing of Multiple Transcripts from Single B Cells /by Brandon DeKosky1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (XXVIII, 87 p. 34 illus.) Springer Theses, Recognizing Outstanding Ph.D. Research,2190-50533-319-58517-7 Includes bibliographical references at the end of each chapters and index.Background -- High-throughput Sequencing of the Paired Human Immunoglobulin Heavy and Light Chain Repertoire -- In-Depth Determination and Analysis of the Human Paired Heavy and Light Chain Antibody Repertoire -- Paired VH:VL Analysis of Naïve B Cell Repertoires and Comparison to Antigen-Experienced B Cell Repertoires in Healthy Human Donors -- Conclusions and Future Perspectives -- Appendices.This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells, the author directly addresses the limitations to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. Previous methods for high-throughput immune repertoire sequencing have been unable to provide such information. The techniques developed in this thesis have enabled comprehensive investigation of human B-cell repertoires and have been applied for the rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053ImmunoglobulinsGenetic engineeringHuman geneticsCytologyBiochemistryAntibodieshttps://scigraph.springernature.com/ontologies/product-market-codes/B14010Genetic Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/C12037Human Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Cell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008Biochemistry, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/L14005Immunoglobulins.Genetic engineering.Human genetics.Cytology.Biochemistry.Antibodies.Genetic Engineering.Human Genetics.Cell Biology.Biochemistry, general.616.0798DeKosky Brandonauthttp://id.loc.gov/vocabulary/relators/aut979631MiAaPQMiAaPQMiAaPQBOOK9910253930203321Decoding the Antibody Repertoire2234127UNINA