03808nam 22006735 450 991025390800332120200706090053.0981-10-4310-810.1007/978-981-10-4310-9(CKB)3710000001411800(DE-He213)978-981-10-4310-9(MiAaPQ)EBC4882815(PPN)202991326(EXLCZ)99371000000141180020170621d2017 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierRNA Activation /edited by Long-Cheng Li1st ed. 2017.Singapore :Springer Singapore :Imprint: Springer,2017.1 online resource (XIV, 239 p. 45 illus., 38 illus. in color.) Advances in Experimental Medicine and Biology,0065-2598 ;983981-10-4309-4 Includes bibliographical references at the end of each chapters and index.PART I Exogenous RNAa -- PART II Endogenous RNAa -- PART III RNA activation guided by other small RNAs -- PART IV Developing RNAa-based therapeutics -- .This book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs). With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development. .Advances in Experimental Medicine and Biology,0065-2598 ;983Gene expressionBiochemistryCytologyMolecular biologyCancerResearchGene Expressionhttps://scigraph.springernature.com/ontologies/product-market-codes/B12010Biochemistry, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/L14005Cell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Gene expression.Biochemistry.Cytology.Molecular biology.CancerResearch.Gene Expression.Biochemistry, general.Cell Biology.Molecular Medicine.Cancer Research.572.88Li Long-Chengedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910253908003321RNA Activation1993951UNINA