03244nam 22005415 450 991025389480332120250609112123.01-4939-3649-210.1007/978-1-4939-3649-6(CKB)3710000000777361(DE-He213)978-1-4939-3649-6(MiAaPQ)EBC4626041(PPN)194802205(MiAaPQ)EBC6241654(EXLCZ)99371000000077736120160805d2016 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierProtein Tyrosine Phosphatases in Cancer /edited by Benjamin G. Neel, Nicholas K. Tonks1st ed. 2016.New York, NY :Springer New York :Imprint: Springer,2016.1 online resource (VIII, 360 p. 28 illus., 19 illus. in color.) 1-4939-3647-6 Includes bibliographical references at the end of each chapters and index.1 Introduction to the PTP Superfamily -- 2 Receptor PTPs in Cancer -- 3 Non-Receptor PTPs in Cancer -- 4 HP2 -- 5 C-PTP -- 6 PTP1B -- 7 PTP-PEST -- 8 Dual Specificity Phosphatases in Cancer -- 9 Phosphatase-dependent roles for PTEN in Cancer -- 10 Phosphatase-independent roles for PTEN in Cancer -- 11 PRL family members in Cancer -- 12 Cdc25 family -- 13 PTPs, metabolism and cancer -- 14 PTPs, metabolism and cancer -- 15 Current status of PTP-based therapeutics -- 16 Summary and Perspective. .This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry. .CancerResearchCytologyPost-translational modificationCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Cell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008Posttranslational Modificationhttps://scigraph.springernature.com/ontologies/product-market-codes/L14090CancerResearch.Cytology.Post-translational modification.Cancer Research.Cell Biology.Posttranslational Modification.614.5999Neel Benjamin Gedthttp://id.loc.gov/vocabulary/relators/edtTonks Nicholas Kedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910253894803321Protein Tyrosine Phosphatases in Cancer2541167UNINA