00869nam 2200265 450 991022825110332120171128131149.020171128d1892----km y0engy50 baengUS 00 A text-book of practical medicinedesigned for the use of students and practitioners of medicineby Alfred L. Loomis8th edition revised and enlargedwith two hundred and fifteen illustrationsNew YorkWilliam Wood and company1892XVII, 1147 p.ill.20 cm.Medicina610Loomis,Alfred Lebbeus747937ITUNINAREICATUNIMARCBK991022825110332190 CCH STORIA MED. 55FMEBCFMEBCA text-book of practical medicine1494821UNINA03676nam 2200973z- 450 991055710240332120210501(CKB)5400000000041023(oapen)https://directory.doabooks.org/handle/20.500.12854/69447(oapen)doab69447(EXLCZ)99540000000004102320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Advances and Applications of OptogeneticsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (164 p.)3-03943-673-2 3-03943-674-0 This book provides an update for the rapidly developing technology known as "optogenetics", which is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various physiological and biochemical processes within the cell. Two ongoing clinical trials use optogenetic tools for vision restoration, and optogenetic strategies have been suggested as novel therapies for several neurological, psychiatric and cardiac disorders. This Special Issue comprises two reviews and seven experimental papers on different types of light-sensitive modules widely used in optogenetic studies. These papers demonstrate the efficiency and versatility of optogenetics and are expected to be equally relevant for advanced users and beginners considering using optogenetic tools in their research.Biology, life sciencesbicsscResearch and information: generalbicsscall-optical electrophysiologyAsLOV2azobenzeneBLUFcalciumcalcium sensorchannelrhodopsinchannelrhodopsin-2channelrhodopsinsChlamydomonas reinhardtiiCTMD method, residual hydrophobic mismatchDC gateelectrophysiologyenergy of membrane deformationflash photolysishippocampal neuronshybrid QM/MM simulationintracellular traffickingion channelion channelsLEXYlight stimulationLINuSLOV domainsmembrane currentmembrane potentialmembrane-protein interactionmicrobial rhodopsinmicrobial rhodopsinsMIPmodular domainmolecular dynamics simulationsneuroscienceneurotransmittersoptogenetic toolsoptogeneticsOptogeneticsp53photocontrolphotoreceptorphotoswitchphotoswitchingPMIprotein-protein interactionresonance Ramansignalingsodiumtwo-photonvoltage sensorBiology, life sciencesResearch and information: generalGovorunova Elena Gedt1320353Sineshchekov Oleg AedtGovorunova Elena GothSineshchekov Oleg AothBOOK9910557102403321The Advances and Applications of Optogenetics3034178UNINA