02836nam 2200409z- 450 991022734820332120231214133411.0(CKB)4100000000883851(oapen)https://directory.doabooks.org/handle/20.500.12854/50092(EXLCZ)99410000000088385120202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierIn Vivo Imaging in Pharmacological ResearchFrontiers Media SA20171 electronic resource (222 p.)Frontiers Research Topics2-88945-237-9 The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development.magnetic resonance imaging (MRI)computerized tomography(CT)positron emission tomography (PET)pharmacologysingle photon emission computed tomography (SPECT)imagingmedical imagingultrasoundNicolau Beckmannauth1325198Albert D. WindhorstauthIgor A. KaltashovauthBOOK9910227348203321In Vivo Imaging in Pharmacological Research3036674UNINA