05553nam 22004935 450 991035023470332120190223141706.0981-13-2068-310.1007/978-981-13-2068-2(CKB)4100000007587918(MiAaPQ)EBC5649657(DE-He213)978-981-13-2068-2(EXLCZ)99410000000758791820190125d2019 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAortic Valve Preservation[electronic resource] Concepts and Approaches /edited by Takashi Kunihara, Shuichiro TakanashiSingapore :Springer Singapore :Imprint: Springer,2019.1 online resource (251 pages)981-13-2067-5 Part I. Introduction -- 1. Anatomy of the Aortic Valve and its Morphological Characteristics -- 2. Pathophysiology and Natural History of Aortic Regurgitation -- 3. Ultrasound Measurement of Aortic Valves -- 4. Computed Tomographic Measurements of Aortic Valves -- 5. Optimizing Aortic Valve Repair Techniques with Computational Models -- 6. Aortoscopy to Evaluate Cusp Configuration after Aortic Valvuloplasty -- 7. Indications and Contraindications for Aortic Valve Repair -- 8. ONE-POINT ADVICE: Significance of Aortic Valvuloplasty in the Valve-in-Valve Era -- 9. Trends in Aortic Valve-sparing Surgery -- Part II. Concepts and Approaches -- 10. Bicuspid Aortic Valve -- 11. ONE-POINT ADVICE: Tricuspidization of a Bicuspid Valve -- 12. Tricuspid Aortic Valve -- 13. Others – Unicuspid valve and Quadricuspid valve -- 14. ONE-POINT ADVICE: The Limitations and Potential of MICS during Aortic Valvuloplasty -- 15. Aortic Valve Reconstruction to Treat Aortic Stenosis Using Autologous Pericardium – Ozaki Procedure -- 16. ONE-POINT ADVICE: Creating a Morphological Template for Autologous Pericardial Cusps -- 17. ONE-POINT ADVICE : Experimental Comparison Between the Reimplantation Method and Remodeling Method -- 18. History, Techniques, and Outcomes of the Reimplantation Method -- 19. History, Techniques, and Outcomes of the Remodeling Method -- 20. Variations and Outcomes of Annuloplasty -- 21. ONE-POINT ADVICE : Other Valve-sparing Aortic Root Replacement Techniques -- 22. ONE-POINT ADVICE : The Advantages and Disadvantages of Valsalva Grafts -- 23. Valve Surgery to Treat Connective Tissue Disease – Comparison Between Valve Replacement and Aortic Root Replacement -- 24. Significance of Aortic Valvuloplasty in the Elderly -- 25. Valve-sparing Aortic Root Replacement to Treat Acute Type A Aortic Dissection -- 26. Pediatric Valvuloplasty -- 27. The Significance of Performing Aortic Valvuloplasty in Young Patients -- Part III. Case Study – What to Do in Each Particular Case? -- 28. How to Manage Patients with Low Geometric Cusp Height -- 29. How to Manage a Stenosed Bicuspid Valve -- 30. How do I Manage a Case with Borderline Dilatation of the Sinus of Valsalva? -- 31. How do I Manage Perforation and Fenestration? -- 32. How to Manage Moderate Aortic Regurgitation in the Context of Combined Valvular Disease -- 33. When is Partial Rremodeling Possible? -- 34. Aortic Valvuloplasty to Treat Aortic Regurgitation Accompanied by a Ruptured Sinus of Valsalva Aneurysm -- 35. Valvuloplasty to Treat Aortic Regurgitation Associated with a Ventricular Septal Defect -- 36. Valvuloplasty for Aortic Regurgitation Associated with Infective Endocarditis -- 37. Valvuloplasty to Treat Traumatic Aortic Regurgitation -- 38. How to Manage Aortic Regurgitation from an Allograft -- Part IV. Aortic Valve Repair: Specialists in the World -- 39. Leaders in Valvuloplasty around the World -- Part V. Closing Remarks -- 40. Cardiologists’ Expectations of Aortic Valvuloplasty.This book provides comprehensive, state-of-the art insights into aortic valvuloplasty. Aortic valve repair is a relatively new procedure. Since first being successfully performed in the 1990s was objectively assessed in the 2000s, this procedure has now become standardized, reproducible, and popular around the globe. Written by experts in surgery and cardiology and richly illustrated, it discusses the aspects of anatomy, pathophysiology, diagnosis and surgical procedure that are essential for successful repair. Contributing to the popularization and development of aortic repair, it is a valuable resource for surgeons, cardiologists, cardio-anesthetists and paramedical staff interested in the field and will be good resource for popularizing and developing aortic valve repair. .HeartSurgeryVascular SurgeryThoracic surgeryCardiac Surgeryhttp://scigraph.springernature.com/things/product-market-codes/H59028Vascular Surgeryhttp://scigraph.springernature.com/things/product-market-codes/H59133Thoracic Surgeryhttp://scigraph.springernature.com/things/product-market-codes/H59095HeartSurgery.Vascular Surgery.Thoracic surgery.Cardiac Surgery.Vascular Surgery.Thoracic Surgery.617.4120597Kunihara Takashiedthttp://id.loc.gov/vocabulary/relators/edtTakanashi Shuichiroedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910350234703321Aortic Valve Preservation1734979UNINA03753nam 2200361z- 450 991022005280332120231214133332.0(CKB)3800000000216249(oapen)https://directory.doabooks.org/handle/20.500.12854/52069(EXLCZ)99380000000021624920202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierLuxR Solos are Becoming Major Players in Cell-Cell Communication in BacteriaFrontiers Media SA20161 electronic resource (122 p.)Frontiers Research Topics2-88919-917-7 The most common quorum sensing (QS) system in Gram-negative bacteria occurs via N-acyl homoserine lactone (AHLs) signals. An archetypical system consists of a LuxI-family protein synthesizing the AHL signal which binds at quorum concentrations to the cognate LuxR-family transcription factors which then control gene expression by binding to specific sequences in target gene promoters. QS LuxR-family proteins are approximately 250 amino acids long and made up of two domains; at the N-terminus there is an autoinducer-binding domain whereas the C-terminus contains a DNA-binding helix-turn-helix (HTH) domain. QS LuxRs display surprisingly low similarities (18-25%) even if they respond to structurally similar AHLs. 95% of LuxRs share 9 highly conserved amino acid residues; six of these are hydrophobic or aromatic and form the cavity of the AHL-binding domain and the remaining three are in the HTH domain. With only very few exceptions, the luxI/R cognate genes of AHL QS systems are located adjacent to each other. The sequencing of many bacterial genomes has revealed that many proteobacteria also possess LuxRs that do not have a cognate LuxI protein associated with them. These LuxRs have been called orphans and more recently solos. LuxR solos are widespread in proteobacterial species that possess a canonical complete AHL QS system as well as in species that do not. In many cases more than one LuxR solo is present in a bacterial genome. Scientists are beginning to investigate these solos. Are solos responding to AHL signals? If present in a bacterium which possesses a canonical AHL QS system are solos an integral part of the regulatory circuit? Are LuxR solos eavesdropping on AHLs produced by neighboring bacteria? Have they evolved to respond to different signals instead of AHLs, and are these signals endogenously produced or exogenously provided? Are they involved in interkingdom signaling by responding to eukaryotic signals? Recent studies have revealed that LuxR solos are involved in several mechanisms of cell-cell communication in bacteria implicating them in bacterial intraspecies and interspecies communication as well as in interkingdom signaling by responding to molecules produced by eukaryotes. LuxR solos are likely to become major players in signaling since they are widespread among proteobacterial genomes and because initial studies highlight their different roles in bacterial communication. This Research Topic allows scientists studying or interested in LuxR solos to report their data and/or express their hypotheses and thoughts on this important and currently understudied family of signaling proteins.LuxR solosQuorum SensingsignalingAHLBacteriaVittorio Venturiauth1332393Brian M.M. AhmerauthBOOK9910220052803321LuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria3040933UNINA