02109nam 2200421z- 450 991022005190332120210211(CKB)3800000000216258(oapen)https://directory.doabooks.org/handle/20.500.12854/52944(oapen)doab52944(EXLCZ)99380000000021625820202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMechanisms of Innate NeuroprotectionFrontiers Media SA20161 online resource (138 p.)Frontiers Research Topics2-88919-929-0 As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.Medicine and NursingbicsscAlzheimermiRNANCXNeuroprotectionpostconditioningpreconditioningseizureStrokeMedicine and NursingGiuseppe Pignataroauth1305930BOOK9910220051903321Mechanisms of Innate Neuroprotection3028031UNINA