00956cam2 22003011 450 SOBE0006501520201203133101.088-420-2377-920201203d1996 |||||ita|0103 baitaIT1Santo Mazzarino8.edRomaBariLaterza1996VII, 430 p.21 cmBiblioteca universale Laterza108001LAEC000152362001 *Biblioteca universale Laterza108001E6002000308072001 <<L' >>Impero Romano / Santo MazzarinoMazzarino, SantoAF00014613070137608ITUNISOB20201203RICAUNISOBUNISOB90090734SOBE00065015M 102 Monografia moderna SBNW900003358-1SI90734rovitoUNISOBUNISOB20201203132854.020201203132916.0rovito11761161UNISOB04421nam 2200433z- 450 991022004040332120210211(CKB)3800000000216373(oapen)https://directory.doabooks.org/handle/20.500.12854/40834(oapen)doab40834(EXLCZ)99380000000021637320202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAnatomy and Plasticity in Large-Scale Brain ModelsFrontiers Media SA20171 online resource (173 p.)Frontiers Research Topics2-88945-065-1 Supercomputing facilities are becoming increasingly available for simulating activity dynamics in large-scale neuronal networks. On today's most advanced supercomputers, networks with up to a billion of neurons can be readily simulated. However, building biologically realistic, full-scale brain models requires more than just a huge number of neurons. In addition to network size, the detailed local and global anatomy of neuronal connections is of crucial importance. Moreover, anatomical connectivity is not fixed, but can rewire throughout life (structural plasticity)-an aspect that is missing in most current network models, in which plasticity is confined to changes in synaptic strength (synaptic plasticity). The papers in this Ebook, which may broadly be divided into three themes, aim to bring together high-performance computing with recent experimental and computational research in neuroanatomy. In the first theme (fiber connectivity), new methods are described for measuring and data-basing microscopic and macroscopic connectivity. In the second theme (structural plasticity), novel models are introduced that incorporate morphological plasticity and rewiring of anatomical connections. In the third theme (large-scale simulations), simulations of large-scale neuronal networks are presented with an emphasis on anatomical detail and plasticity mechanisms. Together, the articles in this Ebook make the reader aware of the methods and models by which large-scale brain networks running on supercomputers can be extended to include anatomical detail and plasticity.Supercomputing facilities are becoming increasingly available for simulating activity dynamics in large-scale neuronal networks. On today's most advanced supercomputers, networks with up to a billion of neurons can be readily simulated. However, building biologically realistic, full-scale brain models requires more than just a huge number of neurons. In addition to network size, the detailed local and global anatomy of neuronal connections is of crucial importance. Moreover, anatomical connectivity is not fixed, but can rewire throughout life (structural plasticity)-an aspect that is missing in most current network models, in which plasticity is confined to changes in synaptic strength (synaptic plasticity). The papers in this Ebook, which may broadly be divided into three themes, aim to bring together high-performance computing with recent experimental and computational research in neuroanatomy. In the first theme (fiber connectivity), new methods are described for measuring and data-basing microscopic and macroscopic connectivity. In the second theme (structural plasticity), novel models are introduced that incorporate morphological plasticity and rewiring of anatomical connections. In the third theme (large-scale simulations), simulations of large-scale neuronal networks are presented with an emphasis on anatomical detail and plasticity mechanisms. Together, the articles in this Ebook make the reader aware of the methods and models by which large-scale brain networks running on supercomputers can be extended to include anatomical detail and plasticity.NeurosciencesbicsscAnatomybrain modelsconnectivityhigh-performance computingsimulationstructural plasticitySupercomputingNeurosciencesArjen van Ooyenauth1353112Markus ButzauthWolfram SchenckauthBOOK9910220040403321Anatomy and Plasticity in Large-Scale Brain Models3220458UNINA