02218nam 2200433z- 450 991022003530332120231214133022.0(CKB)3800000000216424(oapen)https://directory.doabooks.org/handle/20.500.12854/53863(EXLCZ)99380000000021642420202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological DiseaseFrontiers Media SA20171 electronic resource (183 p.)Frontiers Research Topics2-88945-173-9 The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants.Stem Cellsglycine receptorAmyotrophic Lateral SclerosisParkinson's diseasePET imagingLRRK2ZebrafishInflammationGABA-A receptorNMDA receptorsIntellectual DisabilityRobert J. Harveyauth1278463Kirsten HarveyauthBOOK9910220035303321Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease3013298UNINA