01115nam0-2200361---450-99000952305040332120120202110130.0978-88-608-7383-5000952305FED01000952305(Aleph)000952305FED0100095230520120202d2010----km-y0itay50------baitaITy-------001yyNixon, Kissinger e il Medio Oriente(1969-1973)a cura di Antonio Donno e Giuliana IurlanoFirenzeLe Lettere2010514 p.23 cmBiblioteca di nuova storia contemporanea48Stati Uniti d'AmericaRapporti con il Medio Oriente1969-1973Nixon, RichardKissinger, Henry327.730560904522itaDonno,AntonioIurlano,Giuliana<1953- >ITUNINAREICATUNIMARCBK990009523050403321Collez. 2199 (48)47411FSPBCFSPBCNixon, Kissinger e il Medio Oriente856110UNINA05717 am 22006733u 450 991016918100332120170817212524.03-7370-0308-43-8470-0308-9(CKB)2550000001331624(EBL)1744385(SSID)ssj0001413138(PQKBManifestationID)12477467(PQKBTitleCode)TC0001413138(PQKBWorkID)11429653(PQKB)10872669(MiAaPQ)EBC1744385(OCoLC)889268462(ScCtBLL)17677c51-745d-4123-a16c-c4c9cbb058c5(EXLCZ)99255000000133162420140805h20142014 uy 0gerur|n|---|||||txtccrNarratology, hermeneutics, and midrash jewish, christian, and muslim from late antiquity through to modern times /Constanza Cordoni, Gerhard Langer, editorsGöttingen, Germany :V & R unipress :Vienna University Press,2014.©20141 online resource (350 p.)Poetik, Exegese und Narrative Studien zur jüdischen Literatur und Kunst ;Band 2"With one figure"--T.p.3-8471-0308-3 1-306-97458-5 Includes bibliographical references.Title Page; Copyright; Table of Contents; Unbenannt; Body; Constanza Cordoni / Gerhard Langer (Wien): Introduction; Irmtraud Fischer (Graz): Reception of Biblical texts within the Bible: A starting point of midrash?; The art of (late?) biblical narrative as skillful artistic construct of text references; Preliminary remark on defining position and interests; Different interpretations of text-links in different methodologies; Hermeneutical premise; The Bible as "story" tells "history" by using "patterns": some examples; Quotations of "Leitwörter" relevant for exegesis of the later textOccurrence of a phrase in only one other similar contextModelling figures after exemplary characters; Telling stories for interpreting legal texts; Modelling parts of the canon along texts; Consequences for biblical exegesis today; Ilse Muellner (University of Kassel): Celebration and Narration. Metaleptic features in Ex 12:1-13,16; Metalepsis; Historical narrative and feast instructions in Ex 12:1-13:16; The communication structure; Binding of subsequent generations; Feast and memory terminology; Spatial and temporal prolepses; Functions of the metalepsis in biblical narrativesAgnethe Siquans (Wien): Midrasch und Kirchenväter: Parallelen und Differenzen in Hermeneutik und MethodologieDefinitionen: Charakteristika des rabbinischen Midrasch und die patristische Bibelauslegung; Midrasch und Allegorese; Beispieltext: Rabbinische und patristische Auslegung von Ex 1,15-22; Origenes, Homilia II in Exodum; Midrasch Schemot Rabbah 1,13-18; Vergleich der beiden Auslegungen; Die ausgelegten Textteile; Hermeneutische Vorentscheidungen; Methodik; Inhalte; Gemeinsamkeiten und Unterschiede in rabbinischer und patristischer HermeneutikParallelen und Differenzen in der MethodologieSchlussfolgerungen; Carol Bakhos (University of California): Reading Against the Grain: Humor and Subversion in Midrashic Literature; Joshua Levinson (Jerusalem): Post-Classical Narratology and the Rabbinic Subject; Introduction; Historical Context; The Subject in Legal Discourse; Intention and Subjectivity in Midrash Aggadah; Biblical Characters in the Midrash; Exegetical Narrative; Canonicity, Breach and the Disnarrated; History of the Sage as Subject; The Beginnings of Rabbi Eliezer (Genesis Rabbah 41:1); Pirkei de-Rabbi Eliezer; ConclusionAppendix: Pirkei de-Rabbi Eliezer, ch. 1-2Paul Mandel (Jerusalem): Kidors Revenge: Murder, Texts and Rabbis - An Analysis of a Rabbinic Tale and its Transmission (BT Yoma 83b); Introduction; The Tale of Kidor: Babylonian Talmud Yoma 83b; The Parallel Palestinian Traditions; The Tale in the Babylonian Talmud; The Transmission of the Babylonian Tale: Manuscript Versions; The "Other" Tradition and the "Latter Water"; Conclusion: Early or Late Transmission?; Appendix I: The Manuscript Sources of the Narrative (Babylonian Talmud); Version I; Version II; Version IIIMarginal Additions to Version IIIThe contributions compiled in this volume comprise studies of Jewish texts - biblical, rabbinic, medieval, and modern -, as well as of patristic and medieval Christian texts, and in one case, a passage of the Muslim text par excellence, the Quran. The authors, scholars in the fields of Jewish Studies, Catholic and Protestant Theology, Islamic Studies, German philology etc., invited to reflect on texts of their respective disciplines in context-sensitive interpretations, taking into account the link connecting Midrash, hermeneutics, and narrative, provide illuminating narratological and/or hermPoetik, Exegese und Narrative / Poetics, Exegesis and Narrative. Studien zur jüdischen Literatur und Kunst / Studies in Jewish Literature and ArtHermeneuticsHermeneuticsReligious aspects(Produktform)Hardback(VLB-WN)1510: Hardcover, Softcover / Geisteswissenschaften allgemeinHermeneutics.HermeneuticsReligious aspects.289.12589Cordoni ConstanzaLanger GerhardMiAaPQMiAaPQMiAaPQBOOK9910169181003321Narratology, hermeneutics, and midrash2159294UNINA06606nam 2201777z- 450 991055710800332120210501(CKB)5400000000040967(oapen)https://directory.doabooks.org/handle/20.500.12854/69428(oapen)doab69428(EXLCZ)99540000000004096720202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierOpioids and Their ReceptorsPresent and Emerging Concepts in Opioid Drug DiscoveryBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (358 p.)3-0365-0046-4 3-0365-0047-2 The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.Opioids and Their Receptors Medicinebicssc(−)-N-phenethylnorhydromorphone analogs[35S]GTPgammaS assay[Dmt1]DALDA14-methoxycodeine-6-O-sulfate1H-NMR experiments6β-naltrexolabuseagonistallodyniaanalgesiaanalgesicsantagonistarrestin recruitmentbeta-arrestinbias factorbiased agonismbiased agonistbiased agonistsbiased ligandsbiased signalingbifunctional ligandsbindingbinding affinityBNTXbuprenorphinechronic constriction injury (CCI)codeinecodeine-6-O-sulfateDADLEDALDADAMGOdelta opioid receptordependencedesign and synthesisdihydrocodeinediphenethylaminesdockingdysbiosisfentanylforskolin-induced cAMP accumulation assaysfunctional assayG-protein biasheteromerhyperalgesiainteraction fingerprintsinternalizationinverse agonistischemiakappa opioid receptorKGOP01Leu-enkephalinloperamidelysosomesmacrocyclic tetrapeptidemechanism elucidationmisusemitragyninemolecular dockingmolecular dynamicsmolecular modeling &ampMOR and DOR agonistsmorphinanmorphinemu opioid receptormu receptormultifunctional ligandsn/analtrexoneneonatal opioid withdrawal syndromeneurokinin-1 receptorneutral antagonistNTI derivativeopioidopioid drugsopioid liabilitiesopioid peptideopioid peptidesopioid peptides and peptidomimeticsopioid receptorsopioid side effectsopioidsover-the-counter drugspain therapypartial agonismpartial agonistpeptide synthesisperipheral analgesic toleranceperipheral antinociceptionperipheral µ-opioid receptorspharmacologyplasma stabilitypotassium channelsprimary hippocampal culturePZM21racemic synthesis of β2-amino acidsreceptor binding studiesreceptor modelrespirationrespiratory depressionselectivitysimulationSR-17018structure-activity relationshipsstructure-activity relationshipssulfonamideTAPPtolerancewrithing testzerumboneβ-arrestin recruitment assaysβ2-amino acidsβ2-Homo-amino acidsδ opioid receptorδ opioid receptor antagonistμ opioid receptorµ opioid receptorµ-opioid receptorMedicineSpetea Marianaedt1304705Schmidhammer HelmutedtSpetea MarianaothSchmidhammer HelmutothBOOK9910557108003321Opioids and Their Receptors3027635UNINA