01088nam0 22003011i 450 UON0045610720231205105104.930978-86-89613-00-120150619d2013 |0itac50 basrpRS|||| 1||||Kosovo1966-2013Dobrica CosicPriredila Ana Cosic VukicBeogradVukotic media2013348 p. 21 cm.Valore stimatoIT-UONSI SERBOCROATOA/2490KOSOVOUONC038607FIRSBelgradoUONL001000891.82Letteratura serbo-croata21ĆOSIĆDobricaUONV138059636453ĆOSIĆ-VUKIĆAnaUONV152879Vukotic MediaUONV281689650ITSOL20250620RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00456107SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI CROATO A 2490 SI 14129 7 2490 Valore stimatoKosovo1322928UNIOR04091nam 2200457z- 450 991016664540332120210211(CKB)3710000001092145(oapen)https://directory.doabooks.org/handle/20.500.12854/44468(oapen)doab44468(EXLCZ)99371000000109214520202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe CXCR4 Ligand/Receptor Family and the DPP4 Protease in High-Risk Cardiovascular PatientsFrontiers Media SA20161 online resource (163 p.)Frontiers Research Topics2-88919-858-8 Cardiovascular disease (CVD) is the most common cause of morbidity and mortality worldwide, putting a major burden on life quality and social health care systems. Type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) have been identified as important risk factors for CVD, severely increasing the risk on e.g. myocardial infarction, and cardiovascular complications constitute the main cause of death in patients presenting with T2DM, CKD or a combination of both. As these pathologies are expected to rise alarmingly in the next decades, a better understanding of molecular and cellular mechanisms contributing to T2DM, CKD and CVD is required to improve prevention and treatment of these diseases. Furthermore, insight into the interplay between these pathologies and identification of molecular players interconnecting these comorbidities is of tremendous importance for optimal health management in the future. This Research Topic will focus on the chemokine receptor CXCR4 and its ligands CXCL12/SDF-1a and macrophage migration inhibitory factor (MIF) in the context of CVD and its link with T2DM and CKD, as well as address dipeptidyl peptidase-4 (DPP4) as an important protease destabilizing CXCL12. Chemokines and their receptors are important mediators of cell mobilization, recruitment and arrest, and also more broadly induce cell activation by triggering various intracellular signalling tracks. They control homeostatic conditions, but are also critically involved in inflammatory and pathological processes. Genome-wide association studies revealed single nucleotide polymorphisms connecting CXCL12 as well as MIF with CVD, and a role for both chemokines in T2DM and CKD has also been reported. In this review collection, current knowledge on molecular aspects of the CXCR4 ligand/receptor family and associated signalling pathways will be discussed. The physiological roles of CXCR4, CXCL12, MIF and DPP4 will be summarized, and recent findings on their function in pathological conditions of CVD, T2DM and CKD will be highlighted. This is combined with an extensive introduction providing insight into the pathologies of CVD, T2DM and CKD, discussing clinical features and common pathological aspects of these comorbidities on cellular and molecular level. Also, an overview of available animal models to study these diseases will be provided. This way, this Research Topic summarizes latest knowledge on this crucial molecular axis and its relationship with cardiovascular pathologies for both specialists and interested non-specialists and aims to stimulate further initiatives to unravel the mechanistic involvement of the CXCR4 ligand/receptor family in these morbidities, potentially paving the way for new therapeutical initiatives in the future.Medicine and Nursingbicssccardiovascular diseasechemokinechemokine receptorCXCL12/SDF-1CXCR4diabetesdipeptidyl peptidaseDPP4/CD26kidney diseaseMIFMedicine and NursingJurgen Bernhagenauth1325580Heidi NoelsauthBOOK9910166645403321The CXCR4 Ligand3036987UNINA