03564nam 22006855 450 991016415890332120200701015624.010.1007/978-3-319-50693-7(CKB)3710000001053496(DE-He213)978-3-319-50693-7(MiAaPQ)EBC4803157(PPN)198864892(EXLCZ)99371000000105349620170209d2017 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierFree Fatty Acid Receptors /edited by Graeme Milligan, Ikuo Kimura1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (VIII, 256 p. 70 illus.) Handbook of Experimental Pharmacology,0171-2004 ;2363-319-50692-7 3-319-50693-5 Includes bibliographical references at the end of each chapters and index.Ligands at Free Fatty Acid Receptor 1 (GPR40) -- Ligands at Free Fatty Acid Receptor 2/3 (GPR43)/GPR41 -- Ligands at GPR84 -- Ligands at Free Fatty Acid Receptor 4 (GPR120) -- Homology modelling of FFA receptors -- Sensors for FFA receptors -- Key questions for translation of FFA receptors from pharmacology to medicines -- Polymorphic variation in FFA receptors. Functions and consequences -- The role and future of FFA1 as a therapeutic target -- Gut hormone regulation and secretion via FFA1 and FFA4 -- The role of FFA2 and FFA3 in metabolic regulation -- Anti-inflammatory and insulin sensitizing effects of free fatty acid receptors -- Free Fatty Acid receptors and cancer. .This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.Handbook of Experimental Pharmacology,0171-2004 ;236PharmacologyHuman physiologyDiabetesSystems biologyClinical biochemistryPharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Human Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B13004Diabeteshttps://scigraph.springernature.com/ontologies/product-market-codes/H33045Systems Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L15010Medical Biochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/H35005Pharmacology.Human physiology.Diabetes.Systems biology.Clinical biochemistry.Pharmacology/Toxicology.Human Physiology.Diabetes.Systems Biology.Medical Biochemistry.547.437Milligan Graemeedthttp://id.loc.gov/vocabulary/relators/edtKimura Ikuoedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910164158903321Free fatty acid receptors1543391UNINA