03852nam 2200601 450 991015641150332120170124111308.01-61504-740-910.4199/C00148ED1V01Y201612ISP072(CKB)3710000000986517(MiAaPQ)EBC4773097(CaBNVSL)swl00407059(OCoLC)969905972(MOCL)201612ISP072(EXLCZ)99371000000098651720170116h20172017 uy 0engurcnu||||||||rdacontentrdamediardacarrierThe blood-brain barrier in health and disease /William G. Mayhan, Denise M. Arrick[San Rafael, California] :Morgan & Claypool Life Sciences,2017.©20171 online resource (77 pages) illustrations (some color)Colloquium Series on Integrated Systems Physiology: From Molecule to Function,2154-5626 ;Lecture Number 72Part of: Colloquium digital library of life sciences.1-61504-739-5 Includes bibliographical references.1. Introduction -- 2. Characteristics of the blood-brain barrier -- 2.1 Development of the blood-brain barrier -- 2.2 Endothelial transport systems -- 3. Ultrastructural components of the blood-brain barrier -- 3.1 Tight junctional proteins -- 3.1.1 Occludin -- 3.1.2 Claudin -- 3.1.3 Junctional adhesion molecule -- 3.1.4 Accessory proteins -- 3.2 Adherens junctions -- 4. Cellular components of the blood-brain barrier -- 4.1 Astrocytes -- 4.2 Pericytes -- 4.3 Neurons -- 4.4 Microglia -- 5. Compromising the blood-brain barrier -- 5.1 Site of disruption of the blood-brain-barrier -- 5.2 Seizures/acute hypertension -- 5.3 Neuroinflammatory diseases -- 5.4 Diabetes -- 5.5 Traumatic brain injury -- 5.6 Cerebral ischemia/stroke -- 6. Summary -- References -- About the authors.The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the level of adjacent endothelial cells, which are coupled to astrocytes, microglia, neurons and pericytes. The structure of this endothelial barrier is unique among endothelia of other organ systems and is composed of complexes made up of tight, gap and adherens junctions. In addition, it is the responsibility of the surrounding cellular elements to maintain the integrity of the junctional complexes and restrict the entry of substances from the blood into the brain. Changes in permeability of the BBB during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier.Colloquium digital library of life sciences.Colloquium series on integrated systems physiology ;# 72.2154-5626Blood-brain barrierBlood-brain barrier disordersElectronic books.Blood-brain barrier.Blood-brain barrier disorders.612.824Mayhan William G.865112Arrick Denise M.MiAaPQMiAaPQMiAaPQBOOK9910156411503321The blood-brain barrier in health and disease1931011UNINA