03731nam 22005415 450 991025448700332120200701134424.03-319-50353-710.1007/978-3-319-50353-0(CKB)4340000000223199(DE-He213)978-3-319-50353-0(MiAaPQ)EBC5153638(PPN)221253785(EXLCZ)99434000000022319920171122d2017 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierAlternatives for Dermal Toxicity Testing /edited by Chantra Eskes, Erwin van Vliet, Howard I. Maibach1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (XX, 592 p. 92 illus., 61 illus. in color.) 3-319-50351-0 Includes bibliographical references at the end of each chapters.Introduction -- Concepts -- Skin irritation -- Skin corrosion -- Skin sensitization -- UV-induced effects (phototoxicity & photoallergy) -- Skin genotoxicity -- Other exploratory areas of relevance.This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.DermatologyPharmacologyAnimal models in researchDermatologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H1900XPharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Animal Modelshttps://scigraph.springernature.com/ontologies/product-market-codes/L25050Dermatology.Pharmacology.Animal models in research.Dermatology.Pharmacology/Toxicology.Animal Models.616.5Eskes Chantraedthttp://id.loc.gov/vocabulary/relators/edtvan Vliet Erwinedthttp://id.loc.gov/vocabulary/relators/edtMaibach Howard Iedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910254487003321Alternatives for Dermal Toxicity Testing1551254UNINA02759oas 2201009 a 450 991015453390332120260203110035.01543-5180(DE-599)ZDB2030743-3(OCoLC)50409812(CONSER) 2003214673(CKB)991042728191368(DE-599)2030743-3(EXLCZ)9999104272819136820020814b20012018 sy aengurmnu||||||||txtrdacontentcrdamediacrrdacarrierCell communication & adhesion[London] :Gordon and BreachPhiladelphia, Pa. :Taylor & Francis, 2003-Refereed/Peer-reviewedPublished: Philadelphia, Pa. : Taylor & Francis, 2003-1541-9061 Cell communication and adhesionCell commun. adhes.Cell adhesionPeriodicalsCell interactionPeriodicalsCellular signal transductionPeriodicalsCellulesAdhésivitéPériodiquesCellulesInteractionPériodiquesTransduction du signal cellulairePériodiquesHistologyebpsMolecular BiologyebpsCell adhesionfast(OCoLC)fst00850164Cell interactionfast(OCoLC)fst00850189Cellular signal transductionfast(OCoLC)fst00850288Periodicals.fastCell adhesionCell interactionCellular signal transductionCellulesAdhésivitéCellulesInteractionTransduction du signal cellulaireHistology.Molecular Biology.Cell adhesion.Cell interaction.Cellular signal transduction.571Gordon and Breach Science PublishersTaylor & FrancisF#AF#ANSDOCLCQOCLOCLCQMYGNSDLGGPFMOCLCQUKMGBOCLCQOCLCFOCLCQWT2NLEDLCOCLCOAU@VT2NLMOCLCQSRUOCLCQOCLCLXNDUEJOCLCQJOURNAL9910154533903321Cell communication & adhesion2105843UNINA