02046ojm 2200241z- 450 991014893960332120230912161814.00-00-757796-6(CKB)3710000000923355(BIP)045974074(EXLCZ)99371000000092335520231107c2016uuuu -u- -engLabrador: The Story of the World's Favourite DogHarperCollins UKSunday Times Bestseller'Passionate and well-researched' Tatler'A must-read' IndependentA social history of Labradors, and how they have become the world's most beloved dogs, by writer, presenter and long-time dog lover Ben Fogle.Labradors are the most popular breed of dog in the world. Not only a great family companion, they also excel at hunting, tracking, retrieving, guiding and rescuing. But where did the breed originally come from? How did it develop? When did black, yellow and chocolate Labradors first appear? Did they really all come from Labrador in Canada and are they really all related to just one dog?In this first history of the Labrador, Ben Fogle goes in search of what makes Labradors so special. Their extraordinary companionship, intelligence, work ethic and loyalty is captured by Ben as he weaves the story of the breed into his own story of his beloved Inca.Ben visits Canada, discovers hair-raising stories of early Labrador exploits and uncovers stories of RNIB Labradors and Labradors at war, Labradors as working dogs and every other manifestation of the Labrador's character. Exploring their origin, early characteristics, their use as gun dogs, as therapy dogs, as police dogs, as search and rescue dogs and last - and absolutely not least - as family pets, Ben tells the story of a dog breed which has captured our imagination and love for hundreds of years.Labrador636.7527Fogle Benoth1450449AUDIO9910148939603321Labrador: The Story of the World's Favourite Dog3649685UNINA03065nam 2200433z- 450 991013681720332120210211(CKB)3710000000631044(oapen)https://directory.doabooks.org/handle/20.500.12854/53954(oapen)doab53954(EXLCZ)99371000000063104420202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMorphogens in the wiring of the nervous systemFrontiers Media SA20161 online resource (238 p.)Frontiers Research Topics2-88919-781-6 Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules commanding tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring and function in the developing and mature nervous system. Accordingly, dysfunctions of the signaling pathways activated by these molecules contribute to synaptic disassembly and altered function in diseases affecting the nervous system. We consider it timely to bring together cumulative evidence pointing to crucial roles for signaling activated by different morphogens in the establishment of precise contacts between neurons and their synaptic partners. Therefore, this research topic issue combines review and research articles aimed to cover the functional relevance of such morphogens on the different steps involved in synaptic assembly and function. Diverse model systems of physiological or pathological conditions have been included, as well as different cellular, biochemical and molecular approaches. Altogether, they contribute in different and complementary ways to build a holistic view of the roles that early development morphogens play during the assembly, maintenance and/or regeneration of functional synapses.NeurosciencesbicsscBMPMorphogensNervous SystemneurodegenerationNeurogenesisShhsynapseWntNeurosciencesNelson Ossesauth1309752Juan Pablo HenriquezauthBOOK9910136817203321Morphogens in the wiring of the nervous system3029560UNINA