05685nam 2200709Ia 450 991014624430332120230607215341.01-280-55836-93-527-61649-73-527-60063-9(CKB)1000000000019307(EBL)481433(OCoLC)52806916(SSID)ssj0000294364(PQKBManifestationID)11244144(PQKBTitleCode)TC0000294364(PQKBWorkID)10302993(PQKB)10512305(MiAaPQ)EBC481433(Au-PeEL)EBL481433(CaPaEBR)ebr10317845(CaONFJC)MIL55836(EXLCZ)99100000000001930720020531d2002 uy 0engurcn|||||||||txtccrDrug-membrane interactions[electronic resource] analysis, drug distribution, modeling /Joachim K. Seydel and Michael WieseWeinheim Wiley-VCHc20021 online resource (371 p.)Methods and principles in medicinal chemistry ;v. 15Description based upon print version of record.3-527-30427-4 Includes bibliographical references and index.Drug-Membrane Interactions; Contents; Preface; Foreword; Introduction; 1 Function, Composition, and Organization of Membranes; 1.1 The Physiology of Cells and the Importance of Membranes for their Function; 1.2 Composition and Organization of Membranes; 1.2.1 Mammalian Membranes; 1.2.2 Bacterial Membranes; 1.2.3 Fungal Membranes; 1.2.4 Artificial Membranes, Liposome Preparation, and Properties; 1.3 Dynamic Molecular Organization of Membranes; 1.3.1 Thermotropic and Lysotropic Mesomorphism of Phospholipids; 1.3.2 Phase Separation and Domain Formation1.4 Possible Effects of Drugs on Membranes and Effects of Membranes on Drug Molecules References; 2 Octanol-Water Partitioning versus Partitioning into Membranes; References; 3 Analytical Tools for the Analysis and Quantification of Drug-Membrane Interactions; 3.1 High-performance Liquid Chromatography (HPLC); 3.1.1 Determination of the Retention Time on "Artificial Membrane" Columns; 3.2 Displacement of (45)Ca(2+) from Phospholipid Head Groups; 3.2.1 Studies of Drug-Membrane Interactions using Phospholipid Monolayers; 3.3 Differential Scanning Calorimetry (DSC)3.3.1 Phase Transition and Domain Formation 3.4 Fluorescence Techniques; 3.5 Fourier Transform Infrared Spectroscopy (FT-IR); 3.6 Electron Spin Resonance (ESR); 3.7 Small-angle Neutron and X-ray Diffraction; 3.8 Nuclear Magnetic Resonance (NMR); 3.8.1 Study of Membrane Polymorphism by (31)P-NMR; 3.8.2 Effect of Cholesterol and Diacylglycerols; 3.8.3 Effect of Drugs; 3.8.3.1 (31)P-NMR for the Study of Changes in Orientation of Phospholipid Head Group; 3.8.4 Determination of Drug Transmembrane Transport; 3.8.5 (1)H-NMR in Combination with Pr(3+) for the Study of Drug Location3.8.6 The Use of (2)H-NMR and (13)C-NMR to Determine the Degree of Order and the Molecular Dynamics of Membranes 3.8.7 Change in relaxation rate, 1/T2: a Method of Quantifying Drug-Membrane Interaction; 3.8.8 NOE-NMR in the Study of Membrane-induced Changes in Drug Conformation; 3.9 Circular Dichroism (CD); 3.10 UV Spectroscopy; 3.11 Combined Techniques for Studying Drug-Membrane Interaction; 3.11.1 Combination of DSC and NMR; 3.11.2 Combination of DSC and X-ray Diffraction; 3.11.3 Combination of DSC and ESR; 3.11.4 Combination of DSC and Fluorescence; 3.11.5 Combination of FT-IR and NMR3.11.6 Combination of UV and (2)H-NMR 3.11.7 Combination of DSC, FT-IR, and NMR; 3.12 Summary; References; 4 Drug-Membrane Interaction and Pharmacokinetics of Drugs; 4.1 Drug Transport; 4.1.1 Absorption Models; 4.1.1.1 Caco-2 Cells as an Absorption Model; 4.1.1.2 Parallel Artificial Membrane Permeation Assay (PAMPA); 4.1.1.3 Surface Plasmon Resonance Biosensor Technique; 4.1.1.4 The Use of IAM Columns; 4.1.1.5 Partitioning into Immobilized Liposomes; 4.1.2 Computational Methods, QSAR; 4.2 Drug Distribution; 4.2.1 Distribution into the Brain Compartment4.2.2 Distribution, Localization, and Orientation of Drugs in Various Tissues and MembranesBarrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. EfMethods and principles in medicinal chemistry ;v. 15.DrugsStructure-activity relationshipsDrugsMechanism of actionBilayer lipid membranesEffect of drugs onDrugsStructure-activity relationships.DrugsMechanism of action.Bilayer lipid membranesEffect of drugs on.615615.7615.7045Seydel J. K(Joachim Karl)979096Wiese MichaelDr.979097MiAaPQMiAaPQMiAaPQBOOK9910146244303321Drug-membrane interactions2231978UNINA02979nam 2200637Ia 450 991083032100332120230213211245.01-280-25300-297866102530050-471-72522-60-471-72523-4(CKB)1000000000018917(EBL)226561(OCoLC)475932780(SSID)ssj0000104730(PQKBManifestationID)11133285(PQKBTitleCode)TC0000104730(PQKBWorkID)10080029(PQKB)10783478(SSID)ssj0000660900(PQKBManifestationID)11453521(PQKBTitleCode)TC0000660900(PQKBWorkID)10705180(PQKB)11208325(MiAaPQ)EBC226561(EXLCZ)99100000000001891719850719d1982 uy 0engur|n|---|||||txtccrApplied life data analysis[electronic resource] /Wayne NelsonNew York Wileyc19821 online resource (656 p.)Wiley series in probability and mathematical statistics,0271-6356Includes index.0-471-09458-7 Bibliography: p. 603-616.APPLIED LIFE DATA ANALYSIS; Contents; 1. Overview and Background; 2. Basic Concepts and Distributions for Product Life; 3. Probability Plotting of Complete and Singly Censored Data; 4. Graphical Analysis of Multiply Censored Data; 5. Series Systems and Competing Risks; 6. Analysis of Complete Data; 7. Linear Methods for Singly Censored Data; 8. Maximum Likelihood Analysis of Multiply Censored Data; 9. Analyses of Inspection Data (Quantal-Response and Interval Data); 10. Comparisons (Hypothesis Tests) for Complete Data; 11. Comparisons With Linear Estimators (Singly Censored and Complete Data)12. Maximum Likelihood Comparisons (Multiply Censored and Other Data)13. Survey of Other Topics; Appendix A Tables; References; Index; Applied Life Data Analysis is a practical guide to statistical methods for predicting product life and reliability, and comparing improvements in product manufacturing, design, and application. It describes the use of graphical methods, the method of maximum likelihood, censored data analysis, linear estimation, prediction methods, and methods for complete, singly censored, multiply censored, interval, and quantalresponse data.Wiley series in probability and mathematical statistics.Reliability (Engineering)EngineeringReliability (Engineering)Engineering.620/.00452Nelson Wayne1936-105136MiAaPQMiAaPQMiAaPQBOOK9910830321003321Applied life data analysis194937UNINA