01239nam 2200361 450 991014593330332120160621163200.0(CKB)1000000000278932(ItFiC)it 05628148(EXLCZ)99100000000027893220060828d2005 uy 0freLes campagnes napolitaines à la fin du Moyen Âge [electronic resource] mutations d'un paysage rural /Amedeo FenielloRome École française de Rome2005ix, 287 p. illCollection de l'École française de Rome ;348Half title: ISSN 0223-5099.Naples (Campania).2-7283-0686-9 Includes bibliographical references.Land use, RuralItalyNaplesHistoryLand settlementItalyNaplesHistoryNaples (Italy)HistoryTo 1503Land use, RuralHistory.Land settlementHistory.338Feniello Amedeo164241ItFiCItFiCBOOK9910145933303321Les campagnes napolitaines à la fin du Moyen Âge2438320UNINA02210nam 2200457z- 450 991034673490332120210211(CKB)4920000000094361(oapen)https://directory.doabooks.org/handle/20.500.12854/45510(oapen)doab45510(EXLCZ)99492000000009436120202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDrug Repositioning: Current Advances and Future PerspectivesFrontiers Media SA20191 online resource (153 p.)Frontiers Research Topics2-88945-696-X Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.Drug RepositioningPharmacologybicssccomputational analysisdata sharingdatabaseDrug RepositioningIntegrative strategiesmolecular dockingmulti-omicsPatentingpolypharmacologyPharmacologyYuhei Nishimuraauth1305940Hideaki HaraauthBOOK9910346734903321Drug Repositioning: Current Advances and Future Perspectives3028044UNINA