03362nam 2200601Ia 450 991014530760332120170815113959.01-281-13540-297866111354090-470-72520-60-470-72519-2(CKB)1000000000403146(EBL)326422(OCoLC)476124215(SSID)ssj0000203681(PQKBManifestationID)11168935(PQKBTitleCode)TC0000203681(PQKBWorkID)10174440(PQKB)11175449(MiAaPQ)EBC326422(EXLCZ)99100000000040314620080205d2007 uy 0engur|n|---|||||txtccrMitochondrial biology[electronic resource] new perspectives /[editors: Derek J. Chadwick and Jamie Goode]London John Wiley20071 online resource (255 p.)Novartis Foundation symposium ;287Description based upon print version of record.0-470-06657-1 Includes bibliographical references and index.MITOCHONDRIAL BIOLOGY: NEW PERSPECTIVES; Contents; Chair's introduction; Outer mitochondrial membrane protein degradation by the proteasome; DISCUSSION; PA-GFP: a window into the subcellular adventures of the individual mitochondrion; DISCUSSION; Multiple functions of mitochondria-shaping proteins; DISCUSSION; Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators; DISCUSSION; Novel uncoupling proteins; DISCUSSION; Mitochondria as generators and targets of nitric oxide; DISCUSSION; Calcium signalling and mitochondrial motility; DISCUSSIONEndoplasmic reticulum/mitochondria calcium cross-talkDISCUSSION; Mitochondrial ion channels in cardiac function and dysfunction; DISCUSSION; The mitochondrial permeability transition pore; DISCUSSION; Mechanisms of mitochondrial outer membrane permeabilization; DISCUSSION; Mitochondria and neurodegeneration; DISCUSSION; Mitochondrial dysfunction in mammalian ageing; DISCUSSION; Mitochondrial mutations: genotype to phenotype; DISCUSSION; Contributor Index; Subject IndexWith the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especiNovartis Foundation symposium ;287.MitochondriaCell membranesElectronic books.Mitochondria.Cell membranes.571.657Chadwick Derek91632Goode Jamie283336MiAaPQMiAaPQMiAaPQBOOK9910145307603321Mitochondrial biology2131320UNINA