03986nam 2200685Ia 450 991014473970332120170815151020.01-282-12387-497866121238700-470-98557-70-470-98556-9(CKB)1000000000377303(EBL)470483(OCoLC)609849407(SSID)ssj0000360016(PQKBManifestationID)11244187(PQKBTitleCode)TC0000360016(PQKBWorkID)10317795(PQKB)10624946(MiAaPQ)EBC470483(EXLCZ)99100000000037730320070626d2007 uy 0engur|n|---|||||txtccrFatty acids and lipotoxicity in obesity and diabetes[electronic resource] /editors: Gregory Bock and Jamie GoodeLondon John Wiley20071 online resource (223 p.)Novartis Foundation symposium ;286Description based upon print version of record.0-470-05764-5 Includes bibliographical references and index.FATTY ACIDS AND LIPOTOXICITY IN OBESITY AND DIABETES; Contents; Chair's introduction; Transcriptional control of energy homeostasis through the PGC1 coactivators; DISCUSSION; Human obesity and insulin resistance: lessons from experiments of nature; DISCUSSION; Lipid-induced metabolic dysfunction in skeletal muscle; DISCUSSION; Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes; DISCUSSION; The role of lipin 1 in adipogenesis and lipid metabolism; DISCUSSION; The role of the AMP-activated protein kinase in the regulation of energy homeostasis; DISCUSSIONEndoplasmic reticulum stress and inflammation in obesity and type 2 diabetesDISCUSSION; The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis; DISCUSSION; Fatty acid transport in adipocytes and the development of insulin resistance; DISCUSSION; Vectorial acylation: linking fatty acid transport and activation to metabolic trafficking; DISCUSSION; Lipid storage and mobilization pathways in yeast; DISCUSSION; Cide proteins and the development of obesity; DISCUSSION; General discussion I; Visualizing brown adipose tissue with FDG-PETAdiponectin and adiponectin receptors in obesity-linked insulin resistanceDISCUSSION; Anti-inflammatory and antidiabetic roles of PPARy; DISCUSSION; Final Discussion; Nutrition, ageing and lipotoxicity; Contributor Index; Subject IndexThe potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic ß cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics inNovartis Foundation symposium ;286.LipidsMetabolismCongressesFatty acidsCongressesAdipose tissuesCongressesObesityCongressesDiabetesCongressesElectronic books.LipidsMetabolismFatty acidsAdipose tissuesObesityDiabetes612.397Bock Gregory322650Goode Jamie283336MiAaPQMiAaPQMiAaPQBOOK9910144739703321Fatty acids and lipotoxicity in obesity and diabetes2198556UNINA