03925nam 2200673 a 450 991014472880332120170810191413.01-282-12237-197866121223780-470-51396-90-470-51397-7(CKB)1000000000377329(EBL)470475(OCoLC)609849388(SSID)ssj0000357198(PQKBManifestationID)11278551(PQKBTitleCode)TC0000357198(PQKBWorkID)10352935(PQKB)11272117(MiAaPQ)EBC470475(EXLCZ)99100000000037732919900306d1990 uy 0engur|n|---|||||txtccrThe biology of nicotine dependence[electronic resource]Chichester ;New York Wiley19901 online resource (276 p.)Ciba Foundation symposium ;152Proceedings of a symposium held at the Ciba Foundation, London, 7-9 November 1989."A Wiley-Interscience publication."Editors: Greg Bock and Joan Marsh.0-471-92688-4 Includes bibliographical references and indexes.THE BIOLOGY OF NICOTINE DEPENDENCE; Contents; Introduction; Behavioural pharmacology of nicotine: implications for multiple brain nicotinic receptors; Structural and functional heterogeneity of nicotinic receptors; Mechanism of action of the nicotinic acetylcholine receptor; Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists; Presynaptic nicotinic receptors and the modulation of transmitter release; General discussion I : Inactivation of nicotinic cholinergic receptors; Location and function of nicotinic receptors in cultured cortical neuronsRegulation of endocrine function by the nicotinic cholinergic receptorEffects of nicotine on cerebral metabolism; General discussion II : Adaptive and cognitive aspects of the response to nicotine; Mesolimbic dopamine activation-the key to nicotine reinforcement?; Effect of nicotine on dynamic function of brain catecholamine neurons; Pharmacokinetic considerations in understanding nicotine dependence; Nicotine pharmacodynamics: some unresolved issues; Behavioural studies in humans: anxiety, stress and smoking; Final discussion : Withdrawal syndromePossible pharmacological therapies for nicotineUse of transdermal nicotine patches to help people give up smoking; Index of contributors; Subject indexNicotine is considered to be the main agent in the maintenance of the tobacco smoking habit and is largely responsible for the behavioral and physiological responses to the inhalation of tobacco smoke. This work presents advances made in the elucidation of the action of nicotine in the body--essential information for developing treatments to help people give up smoking. The book reviews the progress made in identifying nicotinic acetylcholine receptors in the brain, using the techniques of molecular biology to characterize receptors and investigate the functional differences between receptors Ciba Foundation symposium ;152.NicotinePhysiological effectCongressesNicotinic receptorsCongressesTobacco usePhysiological aspectsCongressesElectronic books.NicotinePhysiological effectNicotinic receptorsTobacco usePhysiological aspects615.78616.865Bock Gregory322650Marsh Joan91633MiAaPQMiAaPQMiAaPQBOOK9910144728803321The biology of nicotine dependence1920522UNINA