03217nam 22006614a 450 991014440920332120240418122551.01-282-00206-697866120020690-470-41129-50-470-41128-7(CKB)1000000000577902(EBL)406462(OCoLC)476225648(SSID)ssj0000180255(PQKBManifestationID)11183633(PQKBTitleCode)TC0000180255(PQKBWorkID)10148673(PQKB)11311742(MiAaPQ)EBC406462(Au-PeEL)EBL406462(CaPaEBR)ebr10275622(CaONFJC)MIL200206(PPN)243323271(EXLCZ)99100000000057790220080527d2009 uy 0engur|n|---|||||txtccrIntegrated cardiac safety[electronic resource] assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance /J. Rick Turner, Todd A. Durham1st ed.Hoboken, N.J. John Wiley & Sonsc20091 online resource (500 p.)Description based upon print version of record.0-470-22964-0 Includes bibliographical references (p. 397-455) and index.The importance of cardiac safety assessments -- The biological basis of adverse drug reactions -- Cardiac structure and function -- Cardiac pathophysiology and disease -- Drug discovery and drug design -- Nonclinical development -- The thorough QT/QTc trial -- General safety assessments -- Therapeutic use trials and meta-analyses -- Assessment methodologies in nonexperimental postmarketing surveillance -- Postmarketing proarrhythmic cardiac safety assessments -- Generalized cardiac safety -- Medication errors, adherence, and concordance -- Future directions in drug safety.The serious nature of cardiovascular adverse drug reactions occurring in patients makes assessment of a drug's cardiac safety profile a high priority during both development and post-approval monitoring. Integrated Cardiac Safety provides necessary guidance and methodology for professionals assessing cardiac safety of drugs throughout all stages of the drug's life, from discovery and development through postmarketing research. This self-contained, reader-friendly text is valuable to professionals in the pharmaceutical, biotechnology, and CRO industries, pharmacologists, toxicologists, gCardiovascular toxicologyHeartEffect of drugs onDrugsSide effectsTestingDrugsSafety measuresCardiovascular toxicology.HeartEffect of drugs on.DrugsSide effectsTesting.DrugsSafety measures.616.1/23061Turner J. Rick281064Durham Todd A970651MiAaPQMiAaPQMiAaPQBOOK9910144409203321Integrated cardiac safety2206214UNINA