03177nam 2200613Ia 450 991014440210332120170815112402.01-282-34275-497866123427520-470-72155-30-470-72156-1(CKB)1000000000579667(EBL)406495(OCoLC)476225856(SSID)ssj0000157792(PQKBManifestationID)11155896(PQKBTitleCode)TC0000157792(PQKBWorkID)10144410(PQKB)11411790(MiAaPQ)EBC406495(EXLCZ)99100000000057966720080707d2008 uy 0engur|n|---|||||txtccrFragment-based drug discovery[electronic resource] a practical approach /editors, Edward R. Zartler, Michael J. ShapiroChichester, U.K. John Wiley & Sons20081 online resource (297 p.)Description based upon print version of record.0-470-05813-7 Includes bibliographical references and index.Fragment-Based Drug Discovery; Contents; List of Contributors; 1 Introduction to Fragment-based Drug Discovery; 2 Designing a Fragment Process to Fit Your Needs; 3 Assembling a Fragment Library; 4 Practical Aspects of Using NMR in Fragment-based Screening; 5 Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses; 6 Target-immobilized NMR Screening: Validation and Extension to Membrane Proteins; 7 In Situ Fragment-based Medicinal Chemistry: Screening by Mass Spectrometry; 8 Computational Approaches to Fragment and Substructure Discovery and Evaluation9 Virtual Fragment Scanning: Current Trends, Applications and Web-based Tools10 Capture Methods for Fragment-based Discovery; 11 Identification of High-affinity -Secretase Inhibitors Using Fragment-based Lead Generation; IndexFragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tiDrug developmentDrugsDesignLigands (Biochemistry)Electronic books.Drug development.DrugsDesign.Ligands (Biochemistry)615.19615/.19Zartler Edward924230Shapiro Michael(Michael J.)67246MiAaPQMiAaPQMiAaPQBOOK9910144402103321Fragment-based drug discovery2074092UNINA