02880oam 22003852a 450 991014432090332120170822141129.00-470-06570-2(CKB)1000000000376406(MH)010734168-9(EXLCZ)99100000000037640620061201d2007 uy 0engFrontier orbitals a practical manual /Nguyen Trong Anh[electronic resource]Chichester, England ;Hoboken, NJ John Wiley & Sons Ltdc20071 online resource (xiv, 287 p. )ill. ;0-471-97358-0 Includes bibliographical references and index.CHAPTER I. What can we do with Frontier Orbitals? -- CHAPTER II. Atomic and molecular orbitals -- CHAPTER III. The perturbation method -- CHAPTER IV. Absolute and relative reactivities -- CHAPTER V. Regioselectivity -- CHAPTER VI. Stereoselectivity -- CHAPTER VII. Some structural problems -- CHAPTER VIII. Going further"Frontier Orbitals is a practical manual intended for tutorial classes or self-studies. Applications are classified by chemical criteria: competition between reagents (relative reactivity, including chemoselectivity), sites (regioselectivity) or reaction trajectories (stereoselectivity). The steps involved in solving each problem, such as the choice of model, the calculation of molecular orbitals, and the interpretation of results, are explained. Numerous exercises are found throughout the text, and the full solutions and references are given in each case. An extensive listing of MOs is also given to allow those without access to a computer to work out the exercises. Practical advice is given for those wishing to do their own calculations." "Frontier Orbitals is aimed at experimentalists who are well versed in organic chemistry but have little or no understanding of quantum mechanics. A greater emphasis is put on chemistry than on quantum mechanics, and the intelligent use of the rules rather than their mathematical derivation. Written by one of the pioneers of the field, Frontier Orbitals is an essential practical guide to the successes and limitations of this theory."--Jacket.Molecular orbitalsPhysical organic chemistryElectronic booksMolecular orbitals.Physical organic chemistry.541/.224Nguyên Trong Anh1935-922098DLCDLCDLCBOOK9910144320903321Frontier orbitals2069212UNINAThis Record contains information from the Harvard Library Bibliographic Dataset, which is provided by the Harvard Library under its Bibliographic Dataset Use Terms and includes data made available by, among others the Library of Congress06027nam 2201477z- 450 991055750480332120210501(CKB)5400000000044508(oapen)https://directory.doabooks.org/handle/20.500.12854/69087(oapen)doab69087(oapen)69087(EXLCZ)99540000000004450820202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAntitumor and Anti-HIV Agents from Natural ProductsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (338 p.)3-03943-008-4 3-03943-009-2 Cancer is the second leading cause of death worldwide, and was accountable for an estimated 9.6 million deaths in 2018. Nowadays, about 1 in 6 deaths in the world is due to cancer. Another major global public health issue is HIV. Over 70 million people have been infected with the HIV virus and about 35 million people have died of HIV-related illness, since the start of the epidemic. We have been fighting against these two serious diseases by finding successful treatments. The discovery of effective drugs is important for fighting cancer and HIV. Natural products, which are secondary metabolites produced by various living organisms, have been playing a principal role in drug discovery and developments, because of their structural and biological diversity. Many clinically used drugs have come from natural products; for example, more than 60% of anticancer drugs currently in clinical use are derived from natural sources. This Special Issue aims to collect original research and review articles focusing on notable and recent contributions to the discovery and development of novel anticancer and anti-HIV drug candidates from natural sources. Up-to-date knowledge from various research fields is welcome. This could be of great interest for scientists working in different research areas, such as natural product chemistry, including isolation and structural elucidation; phytochemistry; medicinal chemistry, including chemically modified natural compounds with improved biological activity; pharmacology; molecular biology; mechanisms of action study using natural products or related compounds; pharmacognosy, etc. Biological studies of natural extracts without an appropriate chemical characterization may not be considered.Research & information: generalbicsscResearch and information: generalbicsscacute toxicityallyl isothiocyanateAngelica dahuricaanti-HIVantiangiogenicantioxidantsantiproliferationantiproliferative activityantiretroviral agentsantitumor activityapoptosisArtemisia absinthium L.aspidosperma-typebenzyl isothiocyanatebladder cancerBousigonia mekongensisBRAF inhibitorbreast cancerbutanolidescaffeic acidcancercancer multidrug resistancecancer stem cellCarpesium divaricatumcell cyclecell cycle arrestcervical cancerchemistrychemopreventioncisplatincoumarinscurcumin analogcytotoxicitydelcosinedelphelinediterpenoid alkaloidsDOTAdrug developmentdrug-drug interactionepithelial-to-mesenchymal transitionessential oilflavonoidsG2/M phase cell cycle arrestHaCaT cellsHEF cell linehepatocellular carcinomahepatoma cellsHernandia nymphaeifoliahuman tumor cell lineshuman tumor cellsinflammationIvalinkobusinelignan glycosideslipojesaconitinemarine metabolitesmatrix metalloproteinasemedicinemelanomamelanoma and breast cancer cell lineMentha aquatica var. Kenting Water Mintmetastasismitochondria-mediated apoptosismonoterpenoid indole alkaloidsnatural agentsnatural phaeosphaeride Anatural productsNF-κBoral squamous cell carcinoma cellsoxidative stressoxypeucedaninP-glycoproteinp53phenethyl isothiocyanatephenolic acidpseudokobusinepterostilbenequercetinreactive oxygen speciesresveratrolSK-Hep-1sulforaphanetamoxifentaxoltotal phenolic contenttransforming growth factor-β1triterpenoidstubulin inhibitortumor suppressiontwo-stage skin carcinogenesisursolic acidβ-lapachoneResearch & information: generalResearch and information: generalNakagawa-Goto Kyokoedt1322913Nakagawa-Goto KyokoothBOOK9910557504803321Antitumor and Anti-HIV Agents from Natural Products3035257UNINA