05309nam 2200649Ia 450 991014409690332120170815111229.01-281-93944-797866119394410-470-69983-30-470-69982-5(CKB)1000000000551348(EBL)366773(OCoLC)476201811(SSID)ssj0000111891(PQKBManifestationID)11143326(PQKBTitleCode)TC0000111891(PQKBWorkID)10080567(PQKB)10215772(MiAaPQ)EBC366773(CaSebORM)9780470027110(PPN)190415940(EXLCZ)99100000000055134820080722d2008 uy 0engur|n|---|||||txtccrBioinformatics for vaccinology[electronic resource] /Darren R. Flower1st editionChichester, West Sussex, England ;Hoboken, NJ John Wiley & Sons20081 online resource (314 p.)Description based upon print version of record.0-470-02711-8 Includes bibliographical references and index.Bioinformatics for Vaccinology; Contents; Preface; Acknowledgements; Exordium; 1 Vaccines: Their place in history; Smallpox in history; Variolation; Variolation in history; Variolation comes to Britain; Lady Mary Wortley Montagu; Variolation and the Sublime Porte; The royal experiment; The boston connection; Variolation takes hold; The Suttonian method; Variolation in Europe; The coming of vaccination; Edward Jenner; Cowpox; Vaccination vindicated; Louis Pasteur; Vaccination becomes a science; Meister, Pasteur and rabies; A vaccine for every disease; In the time of choleraHaffkine and choleraBubonic plague; The changing face of disease; Almroth wright and typhoid; Tuberculosis, Koch, and Calmette; Vaccine BCG; Poliomyelitis; Salk and Sabin; Diphtheria; Whooping cough; Many diseases, many vaccines; Smallpox: Endgame; Further reading; 2 Vaccines: Need and opportunity; Eradication and reservoirs; The ongoing burden of disease; Lifespans; The evolving nature of disease; Economics, climate and disease; Three threats; Tuberculosis in the 21 st century; HIV and AIDS; Malaria: Then and now; Influenza; Bioterrorism; Vaccines as medicinesVaccines and the pharmaceutical industryMaking vaccines; The coming of the vaccine industry; 3 Vaccines: How they work; Challenging the immune system; The threat from bacteria: Robust, diverse, and endemic; Microbes, diversity and metagenomics; The intrinsic complexity of the bacterial threat; Microbes and humankind; The nature of vaccines; Types of vaccine; Carbohydrate vaccines; Epitopic vaccines; Vaccine delivery; Emerging immunovaccinology; The immune system; Innate immunity; Adaptive immunity; The microbiome and mucosal immunity; Cellular components of immunity; Cellular immunityThe T cell repertoireEpitopes: The immunological quantum; The major histocompatibility complex; MHC nomenclature; Peptide binding by the MHC; The structure of the MHC; Antigen presentation; The proteasome; Transporter associated with antigen processing; Class II processing; Seek simplicity and then distrust it; Cross presentation; T cell receptor; T cell activation; Immunological synapse; Signal 1, signal 2, immunodominance; Humoral immunity; Further reading; 4 Vaccines: Data and databases; Making sense of data; Knowledge in a box; The science of -omes and -omics; The proteomeSystems biologyThe immunome; Databases and databanks; The relational database; The XML database; The protein universe; Much data, many databases; What proteins do; What proteins are; The amino acid world; The chiral nature of amino acids; Naming the amino acids; The amino acid alphabet; Defining amino acid properties; Size, charge and hydrogen bonding; Hydrophobicity, lipophilicity and partitioning; Understanding partitioning; Charges, ionization, and pka; Many kinds of property; Mapping the world of sequences; Biological sequence databases; Nucleic acid sequence databasesProtein sequence databases"... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues-making the book enticing and useful, all at once..." Human Vaccines, 2010 ""... This book has severImmunoinformaticsVaccinesDesignData processingImmunoinformatics.VaccinesDesignData processing.572615/.3720285Flower Darren R472707MiAaPQMiAaPQMiAaPQBOOK9910144096903321Bioinformatics for vaccinology226177UNINA