05428nam 2200733Ia 450 991014401090332120210209220356.01-281-08796-31-282-11841-2978661211841897866110879683-527-61147-93-527-61148-7(CKB)1000000000376027(EBL)481656(OCoLC)181348501(SSID)ssj0000156367(PQKBManifestationID)11163136(PQKBTitleCode)TC0000156367(PQKBWorkID)10123604(PQKB)11615160(MiAaPQ)EBC481656(MiAaPQ)EBC4956418(Au-PeEL)EBL4956418(CaONFJC)MIL108796(OCoLC)1027143548(EXLCZ)99100000000037602720070906d2007 uy 0engur|n|---|||||txtccrFoldamers[electronic resource] structure, properties, and applications /edited by Stefan Hecht and Ivan Huc ; foreword by François DiederichWeinheim Wiley-VCHc20071 online resource (459 p.)Description based upon print version of record.3-527-31563-2 Includes bibliographical references and index.Foldamers; Foreword; Contents; Preface; List of Contributors; Part 1 Structure: Foldamer Design Concepts; 1 Foldamers Based on Local Conformational Preferences; 1.1 Introduction; 1.2 Rigidly Locked Molecules; 1.3 Predictable Foldamers; 1.3.1 Local Conformational Control; 1.3.2 Folded Conformations of π-conjugated Systems; 1.3.2.1 Crescents and Helices; 1.3.2.2 Linear Strands; 1.3.2.3 Macrocycles; 1.3.3 Partially π-conjugated Oligomers; 1.4 Semi-rigid Backbones; 1.4.1 Tertiary Aromatic Amides, Imides and Ureas; 1.4.2 Tertiary Aliphatic Amides: Polyprolines and Peptoids1.4.3 Hindered Polymer and Oligomer Backbones1.5 Conformational Transitions; 1.6 Conclusion and Perspectives; References; 2 Foldamers Based on Remote Intrastrand Interactions; 2.1 Introduction; 2.2 What can be Learned from Strategies used to Control Conformations of α-Polypeptides?; 2.3 Helices from Homogeneous Oligomeric Backbones with Periodicity at the Monomer Level: ω-Peptides and their Analogs; 2.3.1 Compact Helices with Large (>10 atoms) H-bonded Rings; 2.3.1.1 The Homologation Strategy: β- and γ-Peptide Foldamers2.3.1.2 Imposing Backbone Conformational Restriction/Pre-organization for Optimal Helical Folding2.3.1.3 Folding in an Aqueous Environment; 2.3.1.4 Dynamics of β- and γ-Peptide Helices: Evidence for Noncooperative Folding/Unfolding Processes; 2.3.2 Extended Helices with Small H-bonded Rings Centered at a Single Residue; 2.3.2.1 α-Peptides: the γ-Helix; 2.3.2.2 ω-Peptides with Specific Conformation-stabilizing Elements; 2.3.2.3 Stabilizing Local Backbone Conformation by Inverse-Bifurcation Involving an Additional Heteroatom; 2.4 Oligoamide Mixed Helices2.4.1 The α-Oligopeptide Precedent: from Antibiotic Gramicidin A to Poly-Gln Aggregates in Huntington's Disease2.4.2 Introducing Periodicity at the Level of a Dimer Unit in β-Peptides leads to a Remarkably Stable Mixed Helical Fold; 2.4.2.1 By Mixing β(2)- and β(3)-Amino Acids; 2.4.2.2 Additional Substitution Patterns Stabilizing the Mixed 10/12- (12/10-) Helix; 2.4.3 Extending the Concept of Mixed Helices; 2.5 Nonperiodic Structures: Open Chain β-Turn-like Motifs and Hairpins in Designed Homo-oligomers; 2.5.1 Sheet-forming ω-peptides; 2.5.2 Turn Segment for Hairpin Formation2.6 Expanding Structural Diversity with Heterogeneous Backbones2.6.1 From Discrete ω-Amino Acid Guests in α-Helices to Helical α,ω- and β,γ-Peptide Hybrids; 2.6.2 Hairpins from α,ω-Peptide Hybrids; 2.6.3 Sculpting New Shapes by Integrating H-Bonding, Aromatic Interactions and Multiple Levels of Pre-organization; 2.7 Conclusion and Outlook; References; 3 Foldamers Based on Solvophobic Effects; 3.1 Introduction; 3.2 Learning from Solvophobically Driven Assemblies - Intermolecular Solvophobic Interactions; 3.3 Learning from Synthetic and Biological Polymers3.4 Recent Advances in Foldamers Based on Solvophobic EffectsThis truly comprehensive treatise of foldamers, from synthesis to applications in bio-, material-, and nanoscience is at once an introduction to the topic, while providing in-depth accounts on various aspects clearly aimed at the specialist.The book is clearly structured, with the first part concentrating on structure and foldamer design concepts, while the second part covers functional aspects from properties to applications. The international team of expert authors provides overviews of synthetic approaches as well as analytical techniques.Chemistry, TechnicalMoleculesModelsOligomersElectronic books.Chemistry, Technical.MoleculesModels.Oligomers.541547.7Hecht Stefan1974-999317Huc Ivan999318MiAaPQMiAaPQMiAaPQBOOK9910144010903321Foldamers2292899UNINA