05131nam 2200613Ia 450 991014396450332120170810192809.01-280-52120-197866105212033-527-60662-93-527-60690-4(CKB)1000000000375904(EBL)481624(OCoLC)85820749(SSID)ssj0000120115(PQKBManifestationID)11131861(PQKBTitleCode)TC0000120115(PQKBWorkID)10080338(PQKB)11050166(MiAaPQ)EBC481624(EXLCZ)99100000000037590420041110d2005 uy 0engur|n|---|||||txtccrCharge transfer in DNA[electronic resource] from mechanism to application /edited by Hans-Achim WagenknechtWeinheim, Germany Wiley-VCHc20051 online resource (247 p.)Description based upon print version of record.3-527-31085-1 Includes bibliographical references and index.Charge Transfer in DNA; Foreword; Preface; Contents; List of Contributors; 1 Principles and Mechanisms of Photoinduced Charge Injection, Transport, and Trapping in DNA; 1.1 Introduction; 1.2 Synthetic DNA-Donor-Acceptor Systems; 1.3 Photoinduced Oxidative Hole Transfer vs. Reductive Electron Transfer in DNA; 1.4 Hole Transfer and Hole Hopping in DNA; 1.4.1 Spectroscopic Studies and Mechanisms of Hole Transfer in DNA; 1.4.2 Biochemical and Chemical Hole Trapping in DNA; 1.4.3 Modulation of DNA-mediated Hole Transfer; 1.5 Reductive Electron Transfer in DNA1.5.1 Mechanisms of Electron Transfer in DNA1.5.2 Outlook: Electron Transfer in DNA Chip Technology; 1.6 Conclusions; References; 2 Sequence-dependent DNA Dynamics: The Regulator of DNA-mediated Charge Transport; 2.1 Introduction; 2.2 Experimental Approaches to Studies of DNA-mediated Charge Transport Over Varied Energetic and Time Regimes; 2.2.1 Metallointercalators, Organic Intercalators, and Modified Bases as Probes; 2.2.1.1 Metallointercalators; 2.2.1.2 Organic Intercalators; 2.2.1.3 Modified Bases; 2.2.2 Spectroscopic, Biochemical, and Electrochemical Approaches2.3 Understanding the Fundamental Parameters Governing DNA-mediated Charge Transport2.3.1 The Base Pair π-Stack of Double-helical DNA Regulates Charge Transport; 2.3.1.1 Spectroscopic Investigations of Charge Transport through DNA; 2.3.1.2 Biochemical Investigations of Long-range Oxidative Damage; 2.3.2 The Role of the Oxidant in DNA-mediated Charge Transport: Energetics, Coupling, Lifetimes, and Back Electron Transfer; 2.3.2.1 Rate Constants and Net Yields of Charge Injection; 2.3.2.2 Long-range Oxidative Damage; 2.3.3 Conformational Dynamics of the DNA Bases2.3.4 Charge Delocalization and Participation of All DNA Bases2.3.5 Transport of Holes Versus "Excess Electrons"; 2.4 A Mechanistic Model for DNA-mediated Charge Transport: Beyond Superexchange and Incoherent Hopping; 2.5 DNA-mediated Charge Transport in Biology; 2.6 Conclusions and Outlook; References; 3 Excess Electron Transfer in DNA Probed with Flavin- and Thymine Dimer-modified Oligonucleotides; 3.1 Introduction; 3.2 Excess Electron Transfer-driven DNA Repair by DNA Photolyases; 3.3 Excess Electron Transfer in DNA; 3.3.1 Distance Dependence; 3.3.2 Directional Dependence3.3.3 Sequence Dependence3.4 The Catalytic Electron? Or, Can One Electron Repair More Than One Dimer Lesion?; 3.5 Future Directions; References; 4 Dynamics of Photoinitiated Hole and Electron Injection in Duplex DNA; 4.1 Introduction; 4.2 DNA Hairpin Synthesis, Structure, and Energetics; 4.2.1 Hairpin Synthesis and Structure; 4.2.2 Electron Transfer Energetics; 4.2.3 Electron Transfer Dynamics; 4.3 Hole Injection; 4.3.1 Distance Dependence; 4.3.2 Electron Donor-Acceptor End-capped Hairpins; 4.3.3 Variation of the Tunneling Energy Gap; 4.3.4 Driving Force Dependence4.3.5 GG and GGG as Hole AcceptorsThe past few years have witnessed intense research in this fascinating field as well as many controversial discussions. Now the time is ripe for a comprehensive book covering not only theoretical aspects, but also such mechanistic topics as principles and mechanisms of photoinduced charge injection, transport and trapping in DNA, sequence-dependent DNA dynamics, spectroscopic investigations of hole transport and much more. From the contents:* Principles and Mechanisms of Photoinduced Charge Injection, Transport and Trapping in DNA* Sequence-Dependent DNA Dynamics: The RegulatorCharge transfer in biologyDNAElectronic books.Charge transfer in biology.DNA.572.86Wagenknecht Hans-Achim863247MiAaPQMiAaPQMiAaPQBOOK9910143964503321Charge transfer in DNA1926967UNINA