03810nam 22006374a 450 991014374010332120181023214754.01-280-23841-097866102384150-470-02139-X0-470-02138-1(CKB)1000000000357242(EBL)239006(OCoLC)475950014(SSID)ssj0000161677(PQKBManifestationID)11170862(PQKBTitleCode)TC0000161677(PQKBWorkID)10200724(PQKB)10393010(MiAaPQ)EBC239006(EXLCZ)99100000000035724220050317d2005 uy 0engur|n|---|||||txtccrGenetics of autoimmunity[electronic resource] /[editors: Gregory Bock and Jamie Goode]Chichester, UK ;Hoboken, NJ, USA Wiley20051 online resource (261 p.)Novartis Foundation symposium ;267"Symposium on Genomics of Autoimmunity, held at the Novartis Foundation, London, 22-24 June 2004."0-470-02137-3 Includes bibliographical references and index.GENETICS OF AUTOIMMUNITY; Contents; Participants; Chair's introduction; Patterns of genetic variation in humans and mice; Discussion; Haplotype tagging in pharmacogenetics; Discussion; Multiple sclerosis: a haplotype association study; Discussion; Mapping genes for asthma and psoriasis; Discussion; Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse; Discussion; The importance of epistatic interactions in the development of autoimmunity; Discussion; Mapping autoimmune disease genes in humans: lessons from IBD and SLE; DiscussionA combined genetics and genomics approach to unravelling molecular pathways in coeliac diseaseDiscussion; Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus; Discussion; A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling; Discussion; Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity; Discussion; An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells; Discussion; Large-scale screens for cDNAs with in vivo activity; DiscussionGenomic mining of new genes and pathways in innate and adaptive immunityDiscussion; Index of contributors; Subject indexThis title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated.Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title:* describes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific* discusses the importance of developing criteria for establishing the significance of these different categories of disease-asNovartis Foundation symposium ;267.AutoimmunityCongressesAutoimmunityGenetic aspectsCongressesElectronic books.AutoimmunityAutoimmunityGenetic aspects616.0796616.978Bock Gregory322650Goode Jamie283336Symposium on Genetics of Autoimmunity(2004 :London, England)MiAaPQMiAaPQMiAaPQBOOK9910143740103321Genetics of autoimmunity1950646UNINA01024nas 2200385 c 450 991089545780332120240131140154.0(CKB)1000000000417198(OCoLC)756339294(DE-101)1015350305(DE-599)ZDB2628851-5(EXLCZ)99100000000041719820110920a19899999 |y |spaur|||||||||||txtrdacontentcrdamediacrrdacarrierVerdolayrevista del Museo Arqueológico de MurciaMurciaMuseo1989-Online-RessourceGesehen am 28.01.151130-9776 Verdolay : Revista del Museo Arqueológico de MurciaRevista de VerdolayZeitschriftgnd-content9300600355DE-1014022JOURNAL9910895457803321Verdolay4248469UNINA