04171nam 2200673Ia 450 991014372330332120170815120524.01-280-35575-197866103557540-470-02923-40-470-02922-6(CKB)1000000000357343(EBL)255332(OCoLC)163585395(SSID)ssj0000264555(PQKBManifestationID)11192258(PQKBTitleCode)TC0000264555(PQKBWorkID)10291333(PQKB)11651827(MiAaPQ)EBC255332(EXLCZ)99100000000035734320060601d2006 uy 0engur|n|---|||||txtccrUnderstanding nicotine and tobacco addiction[electronic resource] /[editors, Gregory Bock and Jamie Goode}Chichester, UK ;Hoboken, NJ John Wiley & Sonsc20061 online resource (285 p.)Novartis Foundation symposium ;275Symposium held at the Novartis Foundation, London, 17-19 May 2005.0-470-01657-4 Includes bibliographical references and indexes.Cover; Contents; Chair's introduction; The hazards of smoking and the benefits of stopping; DISCUSSION; Animal models for nicotine dependence; DISCUSSION; Defining and assessing nicotine dependence in humans; DISCUSSION; General discussion I; Nicotinic acetylcholine receptor functions in the CNS investigated with a novel method of stereotaxic gene re-expression in knockout mice; DISCUSSION; Nicotine-mediated activation of signal transduction pathways; DISCUSSION; Complementary roles for the accumbal shell and core in nicotine dependence; DISCUSSIONThe dopamine D3 system: new opportunities for dopamine-based rewardDISCUSSION; Pathways and systems involved in nicotine dependence; DISCUSSION; Localizing tobacco dependence pathways with functional brain imaging; DISCUSSION; Pharmacogenetic approaches to nicotine dependence treatment; DISCUSSION; Pharmacogenomics and smoking cessation; DISCUSSION; General discussion II; Power in studies; Receptor desensitization; What limits the efficacy of current nicotine replacement therapies?; DISCUSSION; Exploring behavioural mechanisms of nicotine replacement therapy for smoking cessation; DISCUSSIONModifying the metabolism of nicotine as a therapeutic strategyDISCUSSION; Challenges in discovery and development of pharmacotherapies for tobacco addiction; DISCUSSION; Final discussion; Nicotine comorbidity; Animal models; Contributor Index; Subject IndexCigarette smoking is estimated to lead to 4.9 million premature deaths per year worldwide. This is predicted to rise to 10 million by 2020. In western countries it kills half of all smokers who fail to stop.The prevailing model for tobacco addiction is that nicotine from cigarettes rewards smoking and punishes abstinence, tapping into a motivational system of operant conditioning that requires no conscious awareness. However, there are also accounts which involve cognitive biases and the effect of nicotine on impulse control. The brain pathways involved have been studied extensively, bNovartis Foundation symposium ;275.Nicotine addictionCongressesTobacco usePhysiological aspectsCongressesTobacco usePsychological aspectsCongressesSmoking cessationCongressesElectronic books.Nicotine addictionTobacco usePhysiological aspectsTobacco usePsychological aspectsSmoking cessation616.865Bock Gregory322650Goode Jamie283336Symposium on Understanding Nicotine and Tobacco Addiction(2005 :London, England)MiAaPQMiAaPQMiAaPQBOOK9910143723303321Understanding nicotine and tobacco addiction2246794UNINA