05348nam 22006734a 450 991014364310332120180718182823.01-280-54158-X97866105415840-470-02061-X0-470-02062-8(CKB)111090529068402(EBL)189380(OCoLC)475900792(SSID)ssj0000144707(PQKBManifestationID)11147582(PQKBTitleCode)TC0000144707(PQKBWorkID)10146749(PQKB)10514591(MiAaPQ)EBC189380(EXLCZ)9911109052906840220030724d2004 uy 0engur|n|---|||||rdacontentrdamediardacarrierThe eicosanoids[electronic resource] /edited by Peter Curtis-PriorChichester, England ;Hoboken, NJ John Wiley & Sonsc20041 online resource (656 p.)FAO/Wiley Series on Food AgricultureDescription based upon print version of record.0-471-48984-0 Includes bibliographical references and index.The Eicosanoids; Contents; List of Contributors; Preface; Preface from Prostaglandins; Acknowledgements; Foreword; SECTION ONE BIOSYNTHESIS AND METABOLISM; 1 Perspectives on the Biosynthesis and Metabolism of Eicosanoids; 2 Control of Eicosanoid Production by Cellular and Secreted Phospholipase A(2); 3 Mechanisms of PGH Synthase-1 (COX-1) Activity and Role of Radical States; 4 Regulation and Function of Prostaglandin Synthase-2/Cyclooxygenase II; 5 Mammalian Lipoxygenases; 6 Biosynthesis and Biological Effects of 5-oxo-ETE and Other Oxoeicosatetraenoic Acids; 7 Synthetic EicosanoidsSECTION TWO ANALYTICAL METHODS8 Perspectives of Analytical Methods for Eicosanoids; 9 Enzyme Immunoassays of Metabolites and Enzymes Using Acetylcholinesterase as Label; 10 Bioassay of Eicosanoids; 11 Gas Chromatography and Mass Spectrometry in Eicosanoid Analysis; 12 Time-resolved Fluoroimmunoassay in Eicosanoid Analysis; SECTION THREE BIOCHEMICAL AND MOLECULAR PHARMACOLOGY; 13 Perspectives and Clinical Significance of the Biochemical and Molecular Pharmacology of Eicosanoids; 14 Eicosanoid Antagonists15 Biosynthesis and Degradation of Anandamide, an Endogenous Ligand of Cannabinoid Receptors16 Inhibitors of Eicosanoids; 17 Biology and Chemistry of Products of the Isoprostane Pathway; 18 Insight into Prostanoid Functions: Lessons from Receptor-knockout Mice; SECTION FOUR IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC REGULATION; 19 Perspectives and Clinical Significance of Eicosanoids in Immunology, Endocrinology and Metabolic Regulation; 20 Prostaglandins and the Immune Response; 21 Leukotrienes in Aspirin-intolerant Asthma; 22 Essential Fatty Acids23 Endothelial Secretory Function and Atherothrombosis24 Molecular Regulation of Pancreatic Islet Prostaglandin Synthesis and its Relevance to Diabetes Mellitus; 25 Prostaglandins, Leukotrienes and Bone; 26 Ageing and Prostaglandins; SECTION FIVE INFLAMMATION; 27 Perspectives and Clinical Significance of Eicosanoids in Pain and Inflammation; 28 Antiinflammatory Steroids; 29 Eicosanoids and Algesia in Inflammation; 30 Cyclooxygenase-2 in Cancer; 31 Cytokines and Eicosanoids in Arthritis; SECTION SIX CIRCULATORY SYSTEM32 Perspectives and Clinical Significance of Eicosanoids in the Circulatory System33 Aspirin and Activated Platelets; 34 Generation of Vasoactive Prostanoids by the Cyclooxygenase-2 Pathway in the Cardiovascular System of the Rat; 35 Eicosanoid Generation and Effects in Cardiac Muscle and Coronary Vessels; SECTION SEVEN DIGESTIVE SYSTEM; 36 Perspectives and Clinical Significance of Eicosanoids in the Digestive System; 37 Eicosanoids and Liver Regeneration; 38 Eicosanoids and the Intestine; 39 Eicosanoids and Stomach Physiology; SECTION EIGHT NERVOUS SYSTEM40 Perspectives and Clinical Significance of Arachidonic Acid Release, Action and Metabolism in the Nervous SystemThis comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins-NSAIDS (e.g. aspirin) are the biggest selling drugs of allFAO/Wiley Series on Food AgricultureEicosanoidsEicosanoidsPhysiological effectEicosanoidsTherapeutic useElectronic books.Eicosanoids.EicosanoidsPhysiological effect.EicosanoidsTherapeutic use.572.57572/.57Curtis-Prior P. B298830MiAaPQMiAaPQMiAaPQBOOK9910143643103321The eicosanoids2163510UNINA