03599nam 2200601Ia 450 991014358730332120170815120539.01-282-34588-597866123458830-470-06212-60-470-06211-8(CKB)1000000000357117(EBL)290993(OCoLC)144609563(SSID)ssj0000135904(PQKBManifestationID)11139173(PQKBTitleCode)TC0000135904(PQKBWorkID)10065092(PQKB)10782968(MiAaPQ)EBC290993(EXLCZ)99100000000035711720061031d2007 uy 0engur|n|---|||||txtccrDecoding the genomic control of immune reactions[electronic resource]Chichester ;Hoboken, NJ Wiley20071 online resource (230 p.)Novartis Foundation symposium ;281Description based upon print version of record.0-470-02755-X Includes bibliographical references and indexes.Decoding the Genomic Control of Immune Reactions; Contents; Chair's introduction; Transcriptional regulatory networks in macrophages; DISCUSSION; The RIKEN mouse transcriptome: lessons learned and implications for the regulation of immune reactions; DISCUSSION; Molecular pathways for lymphangiogenesis and their role in human disease; DISCUSSION; GENERAL DISCUSSION I; Specifying the patterns of immune cell migration; DISCUSSION; Human monogenic disorders that confer predisposition to specific infections; DISCUSSION; The genetic control of susceptibility to Mycobacterium tuberculosisDISCUSSIONTh2 lymphoproliferative disorders resulting from defective LAT signalosomes; DISCUSSION; Genetic analysis of systemic autoimmunity; DISCUSSION; Genetic resistance to smallpox: lessons from mousepox; DISCUSSION; The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes; DISCUSSION; Genetic control of host-pathogen interactions in mice; DISCUSSION; Mycobacterium tuberculosis and its ability to resist immunity; DISCUSSION; Systems genetics: the next generation in genetics research?; DISCUSSIONRegulation of the immune system in metazoan parasite infectionsDISCUSSION; Closing remarks; Contributor Index; Subject IndexThis book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. Specific Novartis Foundation symposium ;281.ImmunogeneticsCongressesImmunologyCongressesElectronic books.ImmunogeneticsImmunology616.0796Novartis Foundation.MiAaPQMiAaPQMiAaPQBOOK9910143587303321Decoding the genomic control of immune reactions1909568UNINA