03473oam 2200613I 450 991014327080332120230828203409.00-429-12945-91-280-51646-197866105164691-4200-0433-610.1201/9781420004335 (CKB)1000000000345219(EBL)274060(OCoLC)476017823(SSID)ssj0000103661(PQKBManifestationID)11131248(PQKBTitleCode)TC0000103661(PQKBWorkID)10070328(PQKB)11108564(MiAaPQ)EBC274060(OCoLC)84543420(EXLCZ)99100000000034521920180331d2006 uy 0engur|n|---|||||txtccrAnimal models of cognitive impairment /edited by Edward D. Levin, Jerry J. BuccafuscoBoca Raton :CRC/Taylor & Francis,2006.1 online resource (395 p.)Frontiers in neuroscienceDescription based upon print version of record.0-8493-2834-9 Includes bibliographical references and index.Front Cover; Preface; About the Editors; Contributors; Contents; List of Illustrations; 1. Introduction; 2. Muscarinic Receptor Antagonists in Rats; 3. Nicotinic Receptor Antagonists in Rats; 4. Involvement of the NMDA System in Learning and Memory; 5. Animal Models and the Cognitive Effects of Ethanol; 6. Animal Models of Cognitive Impairment Produced by Developmental Lead Exposure; 7. Developmental Behavioral Toxicity of Methylmercury: Consequences, Conditioning, and Cortex8. Executive Function following Developmental Exposure to Polychlorinated Biphenyls (PCBs): What Animal Models Have Told Us9. Modeling Cognitive Deficits Associated with Parkinsonism in the Chronic-Low-Dose MPTP-Treated Monkey; 10. Cognitive Impairment in Transgenic Mouse Models of Amyloid Deposition; 11. Cholinergic Receptor Knockout Mice; 12. Assessments of Cognitive Deficits in Mutant Mice; 13. Cognitive Pharmacology in Aging Macaques; 14. Cognitive Impairment following Traumatic Brain Injury; 15. Cognitive Impairment Models Using Complementary Species16. Cognition Models and Drug DiscoveryIndexThe costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimiFrontiers in neuroscience (Boca Raton, Fla.)Cognition disordersAnimal modelsCognition disordersAnimal models.573.8616.8Levin Edward D1239726Buccafusco Jerry J1236265MiAaPQMiAaPQMiAaPQBOOK9910143270803321Animal models of cognitive impairment2876263UNINA