04440nam 22006494a 450 991014322710332120170815114745.01-280-27406-997866102740620-470-87161-X0-470-87162-8(CKB)111087027098534(EBL)219736(OCoLC)53915219(SSID)ssj0000161463(PQKBManifestationID)11183409(PQKBTitleCode)TC0000161463(PQKBWorkID)10199258(PQKB)10363702(MiAaPQ)EBC219736(EXLCZ)9911108702709853420030724d2003 uy 0engur|n|---|||||txtccrGeneration and effector functions of regulatory lymphocytes[electronic resource] /[editors, Gregory Bock and Jamie Goode]Hoboken, N.J. Wileyc20031 online resource (327 p.)Novartis Foundation symposium ;252Description based upon print version of record.0-470-85074-4 Includes bibliographical references and index.GENERATION AND EFFECTOR FUNCTIONS OF REGULATORY LYMPHOCYTES; Contents; Participants; Chair's introduction; Thymic generation and selection of CD25(+)CD4(+) regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance; Discussion; Control of T cell activation by CD4(+)CD25(+) suppressor T cells; Discussion; Regulation of experimental autoimmune encephalomyelitis (EAE) by CD4(+)CD25(+) regulatory T cells; Discussion; The role of CD28 and CTLA4 in the function and homeostasis of CD4(+)CD25(+) regulatory T cellsDiscussionCD4(+)CD25(+) regulatory cells from human peripheral blood express very high levels of CD25 ex vivo; Discussion; Control of immune pathology by regulatory T cells; Discussion; General discussion I TGFB; Type 1 T regulatory cells and their relationship with CD4(+)CD25(+) T regulatory cells; Discussion; (PRO)insulin-specific regulatory T cells; Discussion; CD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into the mechanisms of protection against Type 1 diabetes; DiscussionSeven surprises in the TCR-centred regulation of immune responsiveness in an autoimmune systemDiscussion; Regulatory cells in transplantation; Discussion; CD4(+) regulatory T cells in chronic viral infection; Discussion; General discussion II; Modulation of T cell responses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship; Discussion; Dendritic cells: controllers of the immune system and a new promise for immunotherapy; Discussion; Regulation of viral and autoimmune responses; Discussion; General discussion III Active immune regulationNotch signalling in the peripheral immune systemDiscussion; CD3 antibody treatment stimulates the functional capability of regulatory T cells; Discussion; The role of dendritic cells in regulating mucosal immunity and tolerance; Discussion; Index of contributors; Subject indexOver the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions areNovartis Foundation symposium ;252.LymphocytesT cellsImmune responseRegulationElectronic books.Lymphocytes.T cells.Immune responseRegulation.571.96Bock Gregory322650Goode Jamie283336MiAaPQMiAaPQMiAaPQBOOK9910143227103321Generation and effector functions of regulatory lymphocytes2000753UNINA