05458nam 2200721Ia 450 991014250550332120170809164910.01-280-36661-397866103666130-470-34865-80-471-46106-70-471-22388-3(CKB)111056485579848(EBL)468979(OCoLC)52400037(SSID)ssj0000261261(PQKBManifestationID)11191975(PQKBTitleCode)TC0000261261(PQKBWorkID)10255822(PQKB)10341944(MiAaPQ)EBC468979(EXLCZ)9911105648557984820000630d2001 uy 0engur|n|---|||||txtccrTranscription factors[electronic resource] normal and malignant development of blood cells /edited by Katya Ravid, Jonathan LichtNew York Wiley-Lissc20011 online resource (642 p.)Includes bibliographical references and index.Includes index.0-471-35054-0 TRANSCRIPTION FACTORS; CONTENTS; Introduction; Contributors; I TRANSCRIPTION FACTORS AND THE MEGAKARYOCYTIC AND ERYTHROID LINEAGES; 1 The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation; 2 Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2; 3 Transcription Factors Involved in Lineage-Specific Gene Expression During Megakaryopoiesis; 4 Role of TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis; 5 EKLF and the Development of the Erythroid Lineage; II TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE6 RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages7 PU.1 and the Development of the Myeloid Lineage; 8 CCAAT/Enhancer-Binding Proteins in Myeloid Cells; 9 Homeobox Gene Networks and the Regulation of Hematopoiesis; 10 The Role of Retinoic Acid Receptors in Myeloid Differentiation; 11 Transcriptional Targets of the Vitamin D(3) Receptor During Myeloid Cell Differentiation; III TRANSCRIPTION FACTORS AND THE LYMPHOID LINEAGE; 12 The Role of Ikaros Family Genes in Lymphopcyte Differentiation and Proliferation13 The Role of PU.1 in B-Lymphocyte Development and Function14 The Role of Pax5 (BSAP) in Early and Late B-Cell Development; 15 Janus Kinases and STAT Family Transcription Factors: Their Role in the Function and Development of Lymphoid Cells; 16 E2A and the Development of B and T Lymphocytes; 17 The Role of BCL-6 in Normal Lymphoid System and non-Hodgkin's Lymphomas; 18 The Role of Octamer Factors and Their Coactivators in the Lymphoid System; 19 The Role of Early B-Cell Factor in B-Lymphocyte Development; IV. TRANSCRIPTION FACTORS INVOLVED IN LEUKEMIAS DUE TO CHROMOSOMAL TRANSLOCATION20 The Role of RARa and Its Fusion Partners in Acute Promyelocytic Leukemia21 The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11; 22 EVI1 Rearrangements in Malignant Hematopoiesis; 23 t(8; 21) AML and the AML1/ETO Fusion Gene: From Clinical Syndrome to Paradigm for the Molecular Basis of Acute Leukemia; 24 TEL/ETV6 Gene Rearrangements in Human Leukemias; 25 MLL in Normal and Malignant Hematopoiesis; 26 Coactivators and Leukemia: The Acetylation Connection with Translocations Involving CBP, p300, TIF2, MOZ, and MLL; 27 The LMO2 Master GeneIts Role as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in Hematopoiesis28 The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations; V. ONCOGENESIS AND HEMATOPOIESIS; 29 The Roles of the c-myc and c-myb Oncogenes in Hematopoiesis and Leukemogenesis; 30 NF-kB in Cell Life and Death; VI. SUMMARY OF TRANSCRIPTION FACTORS IMPLICATED IN HEMATOPOIESIS: IN VIVO STUDIES; 31 Transcription Factors Implicated in Hematopoiesis: In Vivo Studies32 Chromosomal Translocations Associated with Disruption of Transcriptional Regulators in Leukemia and LymphomaThe role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and theHematopoiesisGenetic regulationLeukemiaGenetic aspectsTranscription factorsGenetic transcriptionElectronic books.Hematopoiesis.Genetic regulation.LeukemiaGenetic aspects.Transcription factors.Genetic transcription.612.1/1616.15Ravid Katya883117Licht Jonathan D883118MiAaPQMiAaPQMiAaPQBOOK9910142505503321Transcription factors1972653UNINA