03521nam 2200589 450 991014248420332120170815115235.01-280-55444-497866105544470-470-35936-60-470-84238-50-470-85368-9(CKB)111056485602268(EBL)127935(OCoLC)181838732(SSID)ssj0000161335(PQKBManifestationID)11155000(PQKBTitleCode)TC0000161335(PQKBWorkID)10198879(PQKB)11211953(MiAaPQ)EBC127935(EXLCZ)9911105648560226820160812h19991999 uy 0engur|n|---|||||txtccrGene therapy technologies, applications, and regulations from laboratory to clinic /edited by Anthony MeagerChichester, West Sussex, England :John Wiley & Sons, Ltd,1999.©19991 online resource (439 p.)Description based upon print version of record.0-471-96709-2 Includes bibliographical references at the end of each chapters and index.Gene Therapy Technologies, Applications and Regulations; Contents; List of contributors; Preface; 1 Cationic Liposomes for Gene Therapy Applications; 2 DNA Condensation and Receptor-mediated Gene Transfer; 3 Retroviral Vectors; 4 Lentiviral Vectors; 5 Adenoviral Vectors; 6 Adeno-associated Viral Vectors; 7 Advances in Engineering HSV Vectors for Gene Transfer to the Nervous System; 8 Mammalian Artificial Chromosomes: Prospects for Gene Therapy; 9 Gene Therapy for Severe Combined Immunodeficiency; 10 Gene Therapy for Haemophilia; 11 Cystic Fibrosis: Gene Therapy Approaches12 Therapeutic Approaches to Haemoglobinopathies13 Gene Therapy Approaches to Duchenne Muscular Dystrophy; 14 Lysosomal Storage Diseases; 15 Prospects for Gene Therapy of HIV Infections and AIDS; 16 The Development of the Regulatory Process in Europe for Biological Medicines: how it Affects Gene Therapy Products; 17 Development and Regulation of Gene Therapy Drugs in Germany; 18 The Transfer of Technology from the Laboratory to the Clinic: In process Controls and Final Product Testing; 19 Good Laboratory Practice in the Research and Development Laboratory20 Facilities for Large-scale Production of Vectors Under GMP ConditionsAddendum; IndexGene Therapy Technologies, Applications and Regulations From Laboratory to Clinic Edited by Anthony Meager Division of Immunobiology, The National Institute for Biological Standards and Control, South Mimms, UK The development of gene-based technologies has been rapid over the past decade and has consequently resulted in a surge of interest in human gene therapy, the deliberate transfer of genes to somatic cells to cure or alleviate disease symptoms. Hundreds of clinical protocols involving variously designed vectors for efficient gene transfer have been developed. However, the use of such comGene therapyElectronic books.Gene therapy.616.042616/.042Meager AnthonyMiAaPQMiAaPQMiAaPQBOOK9910142484203321Gene therapy technologies, applications, and regulations2132603UNINA