02436nam 2200601 a 450 991014145020332120200520144314.03-527-65432-11-280-77853-997866136889273-527-65430-53-527-65433-X(CKB)2670000000211558(EBL)945186(OCoLC)809920141(SSID)ssj0000687407(PQKBManifestationID)11437257(PQKBTitleCode)TC0000687407(PQKBWorkID)10735751(PQKB)10201437(MiAaPQ)EBC945186(Au-PeEL)EBL945186(CaPaEBR)ebr10575526(CaONFJC)MIL368892(PPN)178891843(EXLCZ)99267000000021155820120710d2012 uy 0engur|n|---|||||txtccrBioisosteres in medicinal chemistry[electronic resource] /edited by Nathan BrownWeinheim, Germany Wiley-VCH20121 online resource (258 p.)Methods and principles in medicinal chemistry ;v. 54Description based upon print version of record.3-527-33015-1 Includes bibliographical references and index.pt. 1. Principles -- pt. 2. Data -- pt. 3. Methods -- pt. 4. Applications.Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third partcovers the fourMethods and principles in medicinal chemistry ;v. 54.Pharmaceutical chemistryPharmaceutical chemistry.615.19Brown Nathan828243MiAaPQMiAaPQMiAaPQBOOK9910141450203321Bioisosteres in medicinal chemistry2273729UNINA