02841nam 2200733 a 450 991014144940332120200520144314.01-62198-226-21-280-58934-597866136191741-118-28603-01-118-28606-5(CKB)2670000000174713(EBL)843661(OCoLC)787842654(SSID)ssj0000631600(PQKBManifestationID)11428848(PQKBTitleCode)TC0000631600(PQKBWorkID)10599209(PQKB)11154893(MiAaPQ)EBC843661(MiAaPQ)EBC4033812(Au-PeEL)EBL843661(CaPaEBR)ebr10558705(Au-PeEL)EBL4033812(CaPaEBR)ebr11109383(CaONFJC)MIL361917(OCoLC)927507550(iGPub)WILEYB0016391(PPN)17893156X(EXLCZ)99267000000017471320111026d2012 uy 0engur|n|---|||||txtccrAbsorption and drug development solubility, permeability, and charge state /Alex Avdeef2nd ed.Hoboken, N.J. John Wiley & Sonsc20121 online resource (742 p.)Description based upon print version of record.1-118-28596-4 1-118-05745-7 Includes bibliographical references and index.Introduction -- Transport model -- pKa determination -- Octanol-water partitioning -- Liposome-water partitioning -- Solubility -- Permeability - Pampa -- Permeability Caco 2/MDCK -- Permeability blood brain barrier. Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. ThDrugsDesignDrugsMetabolismDrug developmentAbsorptionDrugsDesign.DrugsMetabolism.Drug development.Absorption.615/.19Avdeef Alex521357MiAaPQMiAaPQMiAaPQBOOK9910141449403321Absorption and drug development836551UNINA