03402nam 2200913 a 450 991014144610332120240516151904.03-527-64596-91-280-66289-197866136398203-527-64594-23-527-64597-7(CKB)2670000000178695(EBL)894823(OCoLC)787843753(SSID)ssj0000664125(PQKBManifestationID)12284547(PQKBTitleCode)TC0000664125(PQKBWorkID)10613553(PQKB)11030502(MiAaPQ)EBC894823(Au-PeEL)EBL894823(CaPaEBR)ebr10558733(CaONFJC)MIL363982(PPN)178931829(EXLCZ)99267000000017869520120604d2012 uy 0engur|n|---|||||txtccrProtein-ligand interactions /edited by Holger Gohlke1st ed.Weinheim Wiley-VCH20121 online resource (361 p.)Methods and principles in medicinal chemistry ;v. 53Description based upon print version of record.3-527-32966-8 Includes bibliographical references and index.pt. 1. Binding thermodynamics -- pt. 2. Learning from biophysical experiments -- pt. 3. Modeling protein-ligand interactions -- pt. 4. Challenges in molecular recognition.Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development.The first part provides a basic understanding of the factors governing protein-ligand interaction, followed by a comparison of the four key experimental methods (calorimetry, surface plasmon resonance, NMR and X-ray crystallography) used in generating interaction data. The second half of the book is devoted to in-silico methods of modeling and predicting molecular recognition and binding. Here, as elsewhere in the book, emphasis is placeMethods and principles in medicinal chemistry ;v. 53.ProteinsLigands (Biochemistry)Ligand binding (Biochemistry)DrugsStructure-activity relationshipsCarrier proteinsLigandsProteinspharmacokineticsChemistry Techniques, AnalyticalmethodsCarrier ProteinsProteins.Ligands (Biochemistry)Ligand binding (Biochemistry)DrugsStructure-activity relationships.Carrier proteins.LigandsProteinspharmacokineticsChemistry Techniques, AnalyticalmethodsCarrier Proteins572.6572/.6615.19CHE 802fstubCHE 820fstubCHE 825fstub540sdnb570sdnb610sdnbWD 5100rvkGohlke Holger845725MiAaPQMiAaPQMiAaPQBOOK9910141446103321Protein-ligand interactions1888018UNINA