03178nam 2200613 a 450 991014126600332120200520144314.01-280-59238-997866136222111-118-30983-91-118-30987-11-118-30986-3(CKB)2670000000203832(EBL)832598(OCoLC)793995928(SSID)ssj0000632078(PQKBManifestationID)11386458(PQKBTitleCode)TC0000632078(PQKBWorkID)10599598(PQKB)11718969(MiAaPQ)EBC832598(Au-PeEL)EBL832598(CaPaEBR)ebr10643080(CaONFJC)MIL362221(PPN)178931357(EXLCZ)99267000000020383220111116d2012 uy 0engurcn|||||||||txtccrApplications of transition metal catalysis in drug discovery and development[electronic resource] an industrial perspective /edited by Matthew L. Crawley, Barry M. TrostHoboken, N.J. John Wiley & Sonsc20121 online resource (376 p.)Description based upon print version of record.0-470-63132-5 Includes bibliographical references and index.Transition metal catalysis in the pharmaceutical industry / Carl A. Busacca ... [et al.] -- Selected applications of transition metal-catalyzed carbon-carbon cross-coupling reactions in the pharmaceutical industry / Hong C. Shen -- Selected applications of Pd and Cu-catalyzed carbon-heteroatom cross-coupling reactions in the pharmaceutical industry / Jingjun Yin -- Asymmetric cross-coupling reactions / William A. Szabo and Vince Yeh -- Metathesis / Oliver Thiel -- Transition metal-catalyzed synthesis of five and six membered heterocycles / Cheol K. Chung and Matthew L. Crawley -- Oxidative catalysis / Lamont Terrell -- Industrial asymmetric hydrogenation / Hans-Ulrich Blaser.This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discoveryDrug developmentTransition metal catalystsDrug development.Transition metal catalysts.615.1/9Crawley Matthew L880496Trost Barry M91554MiAaPQMiAaPQMiAaPQBOOK9910141266003321Applications of transition metal catalysis in drug discovery and development1966067UNINA