05120nam 2200613Ia 450 991014097790332120170919153319.01-281-23922-43-527-61172-X3-527-61173-8(CKB)2670000000083319(EBL)482323(OCoLC)609855585(SSID)ssj0000291511(PQKBManifestationID)11235037(PQKBTitleCode)TC0000291511(PQKBWorkID)10253807(PQKB)11213639(MiAaPQ)EBC482323(EXLCZ)99267000000008331920060609d2007 uy 0engur|n|---|||||txtccrChiral separation techniques[electronic resource] a practical approach /edited by Ganapathy Subramanian3rd ed.Weinheim Wiley-VCHc20071 online resource (643 p.)Description based upon print version of record.3-527-31509-8 Includes bibliographical references and index.Chiral Separation Techniques; Contents; Preface; List of Contributors; 1 Method Development and Optimization of Enantioseparations Using Macrocyclic Glycopeptide Chiral Stationary Phases; 1.1 Introduction; 1.2 Structural Characteristics of Macrocyclic Glycopeptide CSPs; 1.2.1 Chiral Recognition Mechanisms; 1.2.2 Multi-modal Chiral Stationary Phases; 1.3 Enantioselectivity as a Function of Molecular Recognition; 1.3.1 Ionizable Molecules; 1.3.1.1 Polar Ionic Mode; 1.3.1.2 Reversed-phase Mode; 1.3.2 Neutral Molecules; 1.4 Complementary Effects; 1.5 Method Development1.6 Optimization Procedures1.6.1 Polar Ionic Mode; 1.6.2 Reversed-phase Mode; 1.6.2.1 pH Effects; 1.6.2.2 Organic Modifier Effects; 1.6.3 Polar Organic/Normal-phase Mode; 1.6.4 Flow-rate and Temperature Effects; 1.7 Amino Acid and Peptide Analysis; 1.8 Conclusion; Acknowledgments; References; 2 Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis; 2.1 Introduction; 2.2 Structures of Polysaccharide Chiral Selectors; 2.2.1 Synthesis of Polysaccharide Chiral Selectors; 2.2.2 Preparation of Polysaccharide Chiral Stationary Phases2.2.2.1 Preparation of CSPs by Coating2.2.2.2 Preparation of CSPs by Immobilization; 2.2.2.3 Coated versus Immobilized CSPs; 2.3 Properties of Polysaccharide CSPs; 2.3.1 Enantioselectivities; 2.3.2 Spectroscopic Studies; 2.4 Applications; 2.4.1 Analytical Separations; 2.4.2 Preparative Separations; 2.5 Optimization of Chiral Separations; 2.5.1 Mobile Phase Compositions; 2.5.2 pH of the Mobile Phase; 2.5.3 Flow-rate; 2.5.4 Temperature; 2.5.5 Structures of Solutes; 2.5.6 Other Parameters; 2.6 Chiral Recognition Mechanisms; 2.7 Chiral Separation by Sub- and Supercritical Fluid Chromatography2.8 Chiral Separation by Capillary Electrochromatography2.9 Chiral Separation by Thin-layer Chromatography; 2.10 Chiral Separation by Capillary Electrophoresis; 2.11 Conclusion; References; 3 Analytical and Preparative Potential of Immobilized Polysaccharide-derived Chiral Stationary Phases; 3.1 Introduction; 3.1.1 Scientific Developments in Polysaccharide Immobilization with Chiral Recognition Purposes; 3.1.2 State of the Art on Immobilized Polysaccharide-derived CSPs; 3.2 Scope of Immobilized Polysaccharide-derived CSPs3.3 Beneficial Characteristics of Immobilized Polysaccharide-derived CSPs3.3.1 New Selectivity Profile on Immobilized CSPs; 3.3.2 Universal Miscibility of Non-standard Solvents and their Contribution to the Performance of Analytical Methods; 3.3.3 Various Sample Injection Media; 3.3.4 Inhibition or Minimization of Racemization by Mobile Phase Switch; 3.3.5 Preparative Potential of Immobilized CSPs; 3.3.6 CSP Stability; 3.4 Method Development on Immobilized Polysaccharide-derived CSPs; 3.4.1 Selection of the Mobile Phase; 3.4.1.1 Analytical Method Development3.4.1.2 Preparative Method DevelopmentThoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.Liquid chromatographyChiralityElectronic books.Liquid chromatography.Chirality.543.84Subramanian G.1935-863248MiAaPQMiAaPQMiAaPQBOOK9910140977903321Chiral separation techniques2029029UNINA02247nas 2200685-a 450 99633434980331620230224213018.01520-8532(OCoLC)39607912(CKB)954927731663(CONSER)sn-98004657-(EXLCZ)9995492773166319980729a19939999 --- aengur|||||||||||txtrdacontentcrdamediacrrdacarrierJournal of the Optical Society of AmericaAOptics, image science, and vision[Washington, D.C.] Optical Society of America©1993-Refereed/Peer-reviewed1084-7529 JOSA AOptics, image science, and visionJournal of the Optical Society of America.OPTICAL SOCIETY OF AMERICA JOURNAL A OPTICS IMAGE SCIENCE AND VISIONJOURNAL OF THE OPTICAL SOCIETY OF AMERICAJ. OPT. SOC. AMER. AJOURNAL OF THE OPTICAL SOCIETY OF AMERICA. A, OPTICS, IMAGE SCIENCE, & VISIONJ OPT SOC AM A OPT IMAGE SCI VISJOURNAL OF THE OPTICAL SOCIETY OF AMERICA AJ OPT SOC AM AJ. OPT. SOC. AM. A-OPT. IMAGE SCI. VISJ. Opt. Soc. Am. A OnlineOpticsPeriodicalsImaging systemsPeriodicalsVisionPeriodicalsOptics and PhotonicsImage EnhancementVision, OcularImaging systemsfast(OCoLC)fst00967605Opticsfast(OCoLC)fst01046845Visionfast(OCoLC)fst01167852Periodicals.fastOpticsImaging systemsVisionOptics and Photonics.Image Enhancement.Vision, Ocular.Imaging systems.Optics.Vision.535Optical Society of America.American Institute of Physics.JOURNAL996334349803316Journal of the Optical society of America104428UNISA