03359nam 2200625Ia 450 991014083210332120200520144314.01-118-04358-81-282-70798-197866127079880-470-76982-30-470-76981-5(CKB)2670000000035575(EBL)564964(OCoLC)662453076(SSID)ssj0000411457(PQKBManifestationID)11271677(PQKBTitleCode)TC0000411457(PQKBWorkID)10357017(PQKB)10892099(MiAaPQ)EBC564964(Au-PeEL)EBL564964(CaPaEBR)ebr10411511(CaONFJC)MIL270798(PPN)240450396(EXLCZ)99267000000003557520100302d2010 uy 0engur|n|---|||||txtccrAggregation of therapeutic proteins[electronic resource] /edited by Wei Wang, Christopher J. RobertsHoboken, NJ Wileyc20101 online resource (514 p.)Description based upon print version of record.0-470-41196-1 Includes bibliographical references and index.AGGREGATION OF THERAPEUTIC PROTEINS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: Fundamental Structures and Behaviors of Proteins; CHAPTER 2: Protein Aggregation Pathways, Kinetics, and Thermodynamics; CHAPTER 3: Identification and Impact of Aggregation-Prone Regions in Proteins and Therapeutic Monoclonal Antibodies; CHAPTER 4: External Factors Affecting Protein Aggregation; CHAPTER 5: Experimental Detection and Characterization of Protein Aggregates; CHAPTER 6: Approaches to Control Protein Aggregation during Bulk ProductionCHAPTER 7: Protein Aggregation and Particle Formation: Effects of Formulation, Interfaces, and Drug Product Manufacturing OperationsCHAPTER 8: Approaches to Managing Protein Aggregation in Product Development; CHAPTER 9: Case Studies Involving Protein Aggregation; CHAPTER 10: Aggregation and Immunogenicity of Therapeutic Proteins; CHAPTER 11: Regulatory Perspective on Aggregates as a Product Quality Attribute; INDEX; color plateThis book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Prevention or even moderate inhibition of protein aggregation has been mostly experimental. The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this arProtein drugsAggregation (Chemistry)Protein drugs.Aggregation (Chemistry)615.5/8Wang Wei1957 Mar. 10-914317Roberts Christopher John1972-914318MiAaPQMiAaPQMiAaPQBOOK9910140832103321Aggregation of therapeutic proteins2048463UNINA