03550nam 2200613Ia 450 991014075340332120230725025123.01-282-84953-097866128495343-527-63234-43-527-63199-23-527-63200-X(CKB)2670000000048021(EBL)589285(SSID)ssj0000434349(PQKBManifestationID)11281646(PQKBTitleCode)TC0000434349(PQKBWorkID)10402054(PQKB)10796084(MiAaPQ)EBC589285(OCoLC)714797095(EXLCZ)99267000000004802120100630d2011 uy 0engur|n|---|||||txtccrChemokine receptors as drug targets /edited by Martine J. Smit, Sergio A. Lira, and Rob LeursWeinheim, Germany Wiley-VCHc20111 online resource (410 p.)Methods and principles in medicinal chemistry ;v. 46Description based upon print version of record.3-527-32118-7 Includes bibliographical references and index.Chemokine Receptors as Drug Targets; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Fundamentals of Chemokines and Chemokine Receptors; 1 Structural Aspects of Chemokines and their Interactions with Receptors and Glycosaminoglycans; 2 Structural Insights for Homology Modeling of Chemokine Receptors; 3 Signaling Events Involved in Chemokine-Directed T Lymphocyte Migration; 4 The Atypical Chemokine Receptors; 5 Targeting Chemokine Receptor Dimers: Are there Two (or More) to Tango?; Part Two: Chemokine Receptors in Disease; 6 Chemokine Receptors in Inflammatory Diseases7 Chemokines and their Receptors in Central Nervous System Disease8 Chemokines and Cancer Metastasis; 9 Constitutively Active Viral Chemokine Receptors: Tools for Immune Subversion and Pathogenesis; Part Three: Targeting Chemokine Receptors; 10 CCR5 Antagonists in HIV; 11 CXCR4 as a Therapeutic Target; 12 Low Molecular Weight CXCR2 Antagonists as Promising Therapeutics; 13 Therapeutic Targeting of the CXCR3 Receptor; 14 Targeting CCR1; 15 Targeting CCR3; 16 Chemokine Binding Proteins as Therapeutics; IndexChemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities.Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in huMethods and principles in medicinal chemistry ;v. 46.ChemokinesReceptorsEffect of drugs onCell receptorsChemokinesReceptorsEffect of drugs on.Cell receptors.616.079Smit Martine J896412Lira Sergio A896413Leurs Rob896414MiAaPQMiAaPQMiAaPQBOOK9910140753403321Chemokine receptors as drug targets2002602UNINA