04822nam 2200673 450 991014034440332120210208170705.01-282-78388-297866127838833-527-64216-13-527-63064-33-527-63063-5(CKB)2580000000000349(EBL)584979(OCoLC)670411404(SSID)ssj0000412275(PQKBManifestationID)11306239(PQKBTitleCode)TC0000412275(PQKBWorkID)10366323(PQKB)10105242(MiAaPQ)EBC584979(EXLCZ)99258000000000034920110110h20102010 uy| 0engur|n|---|||||txtccrAsymmetric catalysis on industrial scale challenges, approaches and solutions /edited by Hans-Ulrich Blaser and Hans-Jürgen Federsel2nd ed.Weinheim :Wiley-VCH,[2010]©20101 online resource (582 p.)Description based upon print version of record.3-527-32489-5 Includes bibliographical references and index.Asymmetric Catalysis on Industrial Scale; Contents; List of Contributors; Introduction; Part I New processes for Existing Active Compounds (APIs); 1 Some Recent Examples in Developing Biocatalytic Pharmaceutical Processes; 2 Enantioselective Hydrogenation: Applications in Process R&D of Pharmaceuticals; 3 Chiral Lactones by Asymmetric Hydrogenation - a Step Forward in (+)-Biotin Production; 4 Biocatalytic Asymmetric Oxidation for the Production of Bicyclic Proline Peptidomimetics10 Development of Efficient Technical Processes for the Production of Enantiopure Amino Alcohols in the Pharmaceutical Industry11 The Asymmetric Hydrogenation of Enones - Access to a New L-Menthol Synthesis; 12 Eliminating Barriers in Large-Scale Asymmetric Synthesis; 13 Catalytic Asymmetric Ring Opening: A Transfer from Academia to Industry; 14 Asymmetric Baeyer-Villiger Reactions Using Whole-Cell Biocatalysts; 15 Large-Scale Applications of Hydrolases in Biocatalytic Asymmetric Synthesis; 16 Scale-Up Studies in Asymmetric Transfer Hydrogenation17 2,2 ,5,5 -Tetramethyl-4,4 -bis(diphenylphoshino)-3,3 -bithiophene: A Very Efficient Chiral Ligand for Ru-Catalyzed Asymmetric Hydrogenations on the Multi-Kilograms Scale18 The Power of Whole-Cell Reaction: Efficient Production of Hydroxyproline, Sugar Nucleotides, Oligosaccharides, and Dipeptides; 19 Enantioselective Ketone Hydrogenation: from Research to Pilot Scale with Industrially Viable Ru-(Phosphine-Oxazoline) Complexes; Part III Processes for New Chemical Entities (NCEs); 20 Enabling Asymmetric Hydrogenation for the Design of Ef.cient Synthesis of Drug Substances21 Scale-up of a Telescoped Enzymatic Hydrolysis Process for an Intermediate in the Synthesis of a Factor Xa Inhibitor22 An Efficient, Asymmetric Synthesis of Odanacatib, a Selective Inhibitor of Cathepsin K for the Treatment of Osteoporosis, Using an Enzyme-Mediated Dynamic Kinetic Resolution; 23 Biocatalytic Routes to the GPIIb/IIIa Antagonist Lotrafiban, SB 214857; 24 Discovery and Development of a Catalytic Asymmetric Conjugate Addition of Ketoesters to Nitroalkenes and Its Use in the Large-Scale Preparation of ABT-54625 The Kagan Oxidation - Industrial-Scale Asymmetric Sulfoxidations in the Synthesis of Two Related NK1/NK2 AntagonistsThis second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found.The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the cataEnantioselective catalysisAsymmetric synthesisEnantioselective catalysisIndustrial applicationsCase studiesElectronic books.Enantioselective catalysis.Asymmetric synthesis.Enantioselective catalysisIndustrial applications547.1395Blaser H. U.Federsel Hans-JurgenMiAaPQMiAaPQMiAaPQBOOK9910140344403321Asymmetric catalysis on industrial scale85703UNINA