01185cam0-22003851i-450-99000328039040332120061109122647.0000328039FED01000328039(Aleph)000328039FED0100032803920030910d1956----km-y0itay50------baitaITa-------001yy<<La >>media ed alta valle del Bifernostudio antropogeograficoLuigi RanieriRomaCNR1956183 p.ill.25 cmMemorie di geografia antropica12In testa al front.: Consiglio Nazionale delle ricerche, Centro di studi per la geografia antropicaPresentazione di Roberto AlmagiaValle del Biferno021.014Ranieri,Luigi<1910-1978>33263ITUNINARICAUNIMARCBK990003280390403321021.014.RANs.i.DECGER'-05i-005(1)Ist. 5894ILFGE01 GEOG 69683DINSTDECGEILFGEDINSTMedia ed alta valle del Biferno451324UNINA05608nam 2200685Ia 450 991013970540332120230802004447.01-283-45393-297866134539381-118-18034-81-118-18035-61-118-18032-1(CKB)2550000000082781(EBL)818517(OCoLC)775869352(SSID)ssj0000611901(PQKBManifestationID)11388652(PQKBTitleCode)TC0000611901(PQKBWorkID)10667303(PQKB)11526555(MiAaPQ)EBC818517(MiAaPQ)EBC4032645(Au-PeEL)EBL818517(CaPaEBR)ebr10534012(CaONFJC)MIL345393(EXLCZ)99255000000008278120110809d2012 uy 0engur|n|---|||||txtccrForward-time population genetics simulations[electronic resource] methods, implementation, and applications /Bo Peng, Marek Kimmel, Christopher I. AmosHoboken, N.J. Wiley Blackwellc20121 online resource (258 p.)Description based upon print version of record.0-470-50348-3 Includes bibliographical references and index.FORWARD-TIME POPULATION GENETICS SIMULATIONS: Methods, Implementation, and Applications; CONTENTS; PREFACE; ACKNOWLEDGMENTS; LIST OF EXAMPLES; 1 BASIC CONCEPTS AND MODELS; 1.1 Biological and Genetic Concepts; 1.1.1 Genome and Chromosomes; 1.1.2 Genes, Markers, Loci, and Alleles; 1.1.3 Recombination and Linkage; 1.1.4 Sex Chromosomes; 1.1.5 Mutation and Mutation Models; 1.2 Population and Evolutionary Genetics; 1.2.1 Population Variation and Mutation; 1.2.2 The Wright-Fisher Model and Random Mating; 1.2.3 The Hardy-Weinberg Equilibrium; 1.2.4 Genetic Drift and Effective Population Size1.2.5 Natural Selection1.2.6 Linkage Equilibrium; 1.2.7 Population Structure and Migration; 1.2.8 Demographic History of Human Populations; 1.2.9 Coalescent and Backward-Time Simulations; 1.2.10 Forward-Time Simulations; 1.3 Statistical Genetics and Genetic Epidemiology; 1.3.1 Penetrance Models; 1.3.2 Simple and Complex Genetic Diseases; 1.3.3 Phenotypic, Allelic, and Locus Heterogeneity; 1.3.4 Study Designs of Gene Mapping; References; 2 SIMULATION OF POPULATION GENETICS MODELS; 2.1 Random Genetic Drift; 2.1.1 Dynamics of Allele Frequency and Heterozygosity; 2.1.2 Persistence Time2.2 Demographic Models2.2.1 The Bottleneck Effect; 2.3 Mutation; 2.3.1 A Diallelic Mutation Model; 2.3.2 Multiallelic Mutation Models; 2.4 Migration; 2.4.1 An Island Model of Migration; 2.5 Recombination and Linkage Disequilibrium; 2.6 Natural Selection; 2.6.1 Single-Locus Diallelic Selection Models; 2.6.2 Multilocus Selection Models; 2.7 Genealogy of Forward-Time Simulations; 2.7.1 Genealogy of Haploid Simulations; 2.7.2 Genealogy of Diploid Simulations; References; 3 ASCERTAINMENT BIAS IN POPULATION GENETICS; 3.1 Introduction; 3.2 Methods; 3.2.1 Evolution of a DNA Repeat Locus3.2.2 Conditional Distributions and Ascertainment Bias of Allele Sizes3.2.3 Simulation Method; 3.3 Results; 3.3.1 Summary of Modeling Results; 3.3.2 Comparisons of Empirical Statistics Derived from Human and Chimpanzee Microsatellite Data; 3.4 Discussion and Conclusions; References; 4 OBSERVING PROPERTIES OF EVOLVING POPULATIONS; 4.1 Introduction; 4.1.1 Allelic Spectra of Complex Human Diseases; 4.1.2 An Evolutionary Model of Effective Number of Disease Alleles; 4.1.3 Simulation of the Evolution of ne; 4.2 Simulation of the Evolution of Allele Spectra; 4.2.1 Demographic Models4.2.2 Output Statistics4.2.3 Mutation Models; 4.2.4 Multilocus Selection Models; 4.2.5 Evolve!; 4.2.6 Validation of Theoretical Results; 4.3 Extensions to the Basic Model; 4.3.1 Impact of Demographic Models; 4.3.2 Impact of the Mutation Model; 4.3.3 Impact of Subpopulation Structure; 4.3.4 Impact of Migration; 4.3.5 Distribution of Equilibrium Disease Allele Frequency; 4.3.6 Varying Selection and Mutation Coefficients; 4.3.7 Evolution of Disease Predisposing Loci Under Weak Selection; 4.3.8 Discussion; References; 5 SIMULATING POPULATIONS WITH COMPLEX HUMAN DISEASES; 5.1 Introduction5.2 Controlling Disease Allele Frequencies at the Present GenerationThe only book available in the area of forward-time population genetics simulations-applicable to both biomedical and evolutionary studies The rapid increase of the power of personal computers has led to the use of serious forward-time simulation programs in genetic studies. Forward-Time Population Genetics Simulations presents both new and commonly used methods, and introduces simuPOP, a powerful and flexible new program that can be used to simulate arbitrary evolutionary processes with unique features like customized chromosome types, arbitrary nonrandom mating schemes, virtual subpPopulation geneticsEvolution (Biology)Computer simulationPopulation genetics.Evolution (Biology)Computer simulation.576.5/8Peng Bo1974-925288Kimmel Marek1959-755485Amos Christopher I925289MiAaPQMiAaPQMiAaPQBOOK9910139705403321Forward-time population genetics simulations2077547UNINA03800nam 22008415 450 991078494120332120220428171226.01-282-67241-X97866126724150-230-24675-310.1057/9780230246751(CKB)2670000000032119(EBL)555499(OCoLC)650307444(SSID)ssj0000412193(PQKBManifestationID)12101524(PQKBTitleCode)TC0000412193(PQKBWorkID)10358156(PQKB)10744843(SSID)ssj0001618227(PQKBManifestationID)16348629(PQKBTitleCode)TC0001618227(PQKBWorkID)14921751(PQKB)11504229(DE-He213)978-0-230-24675-1(MiAaPQ)EBC555499(EXLCZ)99267000000003211920160103d2009 u| 0engur|n|---|||||txtccrAsian Empire and British Knowledge[electronic resource] China and the Networks of British Imperial Expansion /by U. Hillemann1st ed. 2009.London :Palgrave Macmillan UK :Imprint: Palgrave Macmillan,2009.1 online resource (273 p.)Cambridge Imperial and Post-Colonial Studies,2635-1633Description based upon print version of record.1-349-29921-9 0-230-20046-X Includes bibliographical references (p. 236-253) and index.Machine generated contents note: Introdcution * The decline of Mythical China * At the China Coast * South and Southeast Asian Encounters * Asian Networks and the British Isles Introdcution * The decline of Mythical China * At the China Coast * South and Southeast Asian Encounters * Asian Networks and the British Isles.British knowledge about China changed fundamentally in the eighteenth and nineteenth centuries. Rather than treating these changes in British understanding as if Anglo-Sino relations were purely bilateral, this study looks at how British imperial networks in India and Southeast Asia were critical mediators in the British encounter of China.Cambridge Imperial and Post-Colonial Studies,2635-1633World politicsHistoriographyHistory, ModernAsian Historyhttps://scigraph.springernature.com/ontologies/product-market-codes/715000History of Britain and Irelandhttps://scigraph.springernature.com/ontologies/product-market-codes/717020Political Historyhttps://scigraph.springernature.com/ontologies/product-market-codes/911080Historiography and Methodhttps://scigraph.springernature.com/ontologies/product-market-codes/711000Modern Historyhttps://scigraph.springernature.com/ontologies/product-market-codes/713000History of Chinahttps://scigraph.springernature.com/ontologies/product-market-codes/715010AsiaHistoryGreat BritainHistoryChinaHistoryWorld politics.Historiography.History, Modern.Asian History.History of Britain and Ireland.Political History.Historiography and Method.Modern History.History of China.303.48/24105109034951.03Hillemann Uauthttp://id.loc.gov/vocabulary/relators/aut1520505BOOK9910784941203321Asian Empire and British Knowledge3759116UNINA