02498nam 2200589 a 450 991013969000332120230802004630.03-527-64478-41-283-45422-X97866134542253-527-64482-23-527-64479-2(CKB)2550000000084138(EBL)851166(OCoLC)775871780(SSID)ssj0000642007(PQKBManifestationID)11458699(PQKBTitleCode)TC0000642007(PQKBWorkID)10628609(PQKB)11613742(MiAaPQ)EBC851166(Au-PeEL)EBL851166(CaPaEBR)ebr10531468(CaONFJC)MIL345422(EXLCZ)99255000000008413820120309d2012 uy 0engur|n|---|||||txtccrTherapeutic proteins[electronic resource] strategies to modulate their plasma half-lives /edited by Roland KontermannWeinheim, Germany Wiley-Blackwell20121 online resource (374 p.)Description based upon print version of record.3-527-32849-1 Includes bibliographical references and index.pt. 1. General information -- pt. 2. Half-life extension through chemical and post-translational modifications -- pt. 3. Half-life modulation involving recycling by the neonatal Fc receptor -- pt. 4. Half-life extension with pharmaceutical formulations.For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.Protein drugsDesignProteinsTherapeutic useProtein drugsDesign.ProteinsTherapeutic use.615.3Kontermann Roland941977MiAaPQMiAaPQMiAaPQBOOK9910139690003321Therapeutic proteins2125405UNINA