04246nam 2200649 a 450 991013962790332120220408232227.01-283-17565-797866131756561-118-02363-31-118-02364-11-118-02362-5(CKB)2550000000041730(EBL)697480(OCoLC)739118473(SSID)ssj0000521990(PQKBManifestationID)12187542(PQKBTitleCode)TC0000521990(PQKBWorkID)10523624(PQKB)11628809(MiAaPQ)EBC697480(Au-PeEL)EBL697480(CaPaEBR)ebr10484637(CaONFJC)MIL317565(PPN)194576183(EXLCZ)99255000000004173020101116d2011 uy 0engur|n|---|||||txtccrDevelopment of vaccines[electronic resource] from discovery to clinical testing /edited by Manmohan Singh, Indresh K. SrivastavaHoboken, N.J. John Wiley & Sonsc20111 online resource (478 p.)Description based upon print version of record.0-470-25637-0 Includes bibliographical references and index.Microbial vaccines design : the reverse vaccinology approach / Roberto Rosini, Michele A. Barocchi, Rino Rappuoli -- Design and development of recombinant vaccines with viral properties / Gerd Lipowsky, Martin F. Bachmann -- Tools for vaccine design : prediction and validation of highly immunogenic and conserved class II epitopes, and development of epitope-driven vaccines / Anne S. De Groot ... [et al.] -- Virus like-particle vaccines advantages and challenges / Ted M. Ross ... [et al.] -- Design platforms of nanocapsules for human therapeutics or vaccines / Masaaki Kawano ... [et al.] -- Designing immunogens for vaccine development in reference to HIV / Aemro Kassa ... [et al.] --Expression and purification of recombinant proteins for vaccine applications / Carlo Zambonelli, Deeann Martinez-Guzmann, and Indresh K. Srivastava -- DNA vaccines for infectious diesase / Samuel Stepenson, Manmohan Singh, Indresh K. Srivastava -- Developing stable cell lines for the production of vaccine antigens / Xiaotian Zhong ... [et al.] -- Spectroscopy of vaccines / C. Russell Middaugh, Sangeeta B. Joshi -- Biophysical characterization of protein antigens within vaccine formulations / Padima Malyala, Derek O'Hagan, Manmohan Singh -- Structural characteristics predict the stability of HIV / Zohar Biron ... [et al.] -- Selection of optimal adjuvants and product factors that affect vaccine immunogenicity / Wei Wang, Manmohan Singh -- Lyophilization and stabilization of vaccines / James Chesko ... [et al.] -- Effect of buffers and stabilizers on vaccine stability and efficacy / Shireesh P. Apte, Sydney Ugwu -- Selection of final product containers / Luis Baez, Adrian Distler -- From the lab to the clinic : filing a phase I IND for an investigational vaccine / Kenneth G. Surowitz.Development of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experienVaccinesDrug developmentDrug stabilityVaccines.Drug development.Drug stability.615/.372Manmohan Singh1964 November 8-1199148Srivasta Indresh K991989MiAaPQMiAaPQMiAaPQBOOK9910139627903321Development of vaccines2818608UNINA