06399nam 22015133u 450 991013961440332120251116164049.01-283-20493-297866132049361-4443-4668-71-4443-4666-0(CKB)2550000000042700(EBL)697793(OCoLC)746326590(SSID)ssj0000537907(PQKBManifestationID)12176511(PQKBTitleCode)TC0000537907(PQKBWorkID)10567429(PQKB)10023227(MiAaPQ)EBC697793(PPN)20451424X(EXLCZ)99255000000004270020130418d2011|||| u|| |engur|n|---|||||txtccrInflammation and Allergy Drug Design1st ed.Chicester Wiley20111 online resource (346 p.)Description based upon print version of record.1-4443-3014-4 Inflammation and Allergy Drug Design; Contents; Contributors; Preface; Part I: Cells contributing to the pathogenesis of allergic diseases in the respiratory tract; 1: Novel anti-inflammatory drugs based on targeting lung dendritic cells and airway epithelial cells; 2: Role of Th2 cells in the allergic diathesis; 3: Importance of Th17-and Th1-associated responses for the development of asthma; 4: Regulatory T cells; 5: A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders; 6: Regulatory roles of B cells in allergy and inflammation; 7: Mast cells8: Eosinophils9: Basophils in inflammation and allergy drug design; 10: Epithelial cells; 11: Fibroblasts; 12: Airway smooth muscle cells; Part II: Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract; 13: Interleukin 4, interleukin 13, and interleukin 9; 14: Interleukin 3, interleukin 5, and granulocyte-macrophage colony-stimulating factor; 15: Interleukin 15, interleukin 17, and interleukin 25; 16: Thymic stromal lymphopoietin; 17: Interleukin 10; 18: Tumor necrosis factor alpha; 19: Profibrotic and angiogenic factors in asthma; 20: Chemokines21: Epithelial growth factorsPart III: Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract; 22: Prostanoids; 23: Leukotrienes; 24: Proteases in allergy; 25: Toll-like receptors; IndexThis book educates the reader on the molecular and cellular mechanism of allergic diseases in the respiratory tract covering all aspects, from its immunological basis to its application in drug development. In contrast to other books, this book focuses on well-known and newly-emerging cells, cytokins, and mediators involved in the pathogenesis of allergic diseases in the respiratory tract. In particular, this book emphasises the findings of novel drug targets. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biologAllergy - TreatmentAllergy -- TreatmentAntiallergic agentsAnti-Allergic AgentsAntiallergic agentsAnti-Allergic AgentsAnti-Inflammatory AgentsAnti-inflammatory agentsAnti-inflammatory agentsDrug DesignDrug DesignDrugs - DesignDrugs -- DesignHypersensitivity - drug therapyHypersensitivity -- drug therapyAntiallergic agentsTreatmentAllergyDesignAnti-inflammatory agentsDrugsDrug DiscoveryTherapeuticsImmune System DiseasesTherapeutic UsesDiseasePharmacologic ActionsInvestigative TechniquesChemistry, PharmaceuticalChemical Actions and UsesPharmacologyChemistryBiological Science DisciplinesNatural Science DisciplinesDrug DesignDrug TherapyAnti-Allergic AgentsAnti-Inflammatory AgentsHypersensitivityHealth & Biological SciencesHILCCPharmacy, Therapeutics, & PharmacologyHILCCAllergy - Treatment.Allergy -- Treatment.Antiallergic agents.Anti-Allergic Agents.Antiallergic agents.Anti-Allergic Agents.Anti-Inflammatory Agents.Anti-inflammatory agents.Anti-inflammatory agents.Drug Design.Drug Design.Drugs - Design.Drugs -- Design.Hypersensitivity - drug therapy.Hypersensitivity -- drug therapy.Antiallergic agentsTreatment.AllergyDesign.Anti-inflammatory agents.Drugs.Drug Discovery.Therapeutics.Immune System Diseases.Therapeutic Uses.Disease.Pharmacologic Actions.Investigative Techniques.Chemistry, Pharmaceutical.Chemical Actions and Uses.Pharmacology.Chemistry.Biological Science Disciplines.Natural Science Disciplines.Drug Design.Drug Therapy.Anti-Allergic Agents.Anti-Inflammatory Agents.Hypersensitivity.Health & Biological SciencesPharmacy, Therapeutics, & Pharmacology615.7615.794615/.7Izuhara K927569Holgate S. T878514Wills-Karp Marsha927570AU-PeELAU-PeELAU-PeELBOOK9910139614403321Inflammation and Allergy Drug Design4476274UNINA