03423nam 2200601Ia 450 991013961200332120231117103258.01-283-25775-097866132577581-118-06389-91-118-06390-21-118-06388-0(CKB)2550000000043360(EBL)697534(OCoLC)818811902(SSID)ssj0000540459(PQKBManifestationID)11390981(PQKBTitleCode)TC0000540459(PQKBWorkID)10585799(PQKB)11768903(MiAaPQ)EBC697534(PPN)171971795(EXLCZ)99255000000004336020110131d2011 uy 0engur|n|---|||||txtccrProtein chaperones and protection from neurodegenerative diseases /edited by Stephan WittHoboken John Wiley & Sonsc20111 online resource (448 p.)Wiley series on protein and peptide scienceDescription based upon print version of record.0-470-56907-7 Includes bibliographical references and index.PROTEIN CHAPERONES AND PROTECTION FROM NEURODEGENERATIVE DISEASES; CONTENTS; Preface; Introduction; Contributors; 1 Intrinsically Disordered Chaperones and Neurodegeneration; 2 Redox Regulation of Protein Misfolding, Synaptic Damage, and Neuronal Loss in Neurodegenerative Diseases; 3 Chaperone-Mediated Autophagy and Parkinson's Disease; 4 Chaperone and Anti-Chaperone Properties of Synuclein: Implications for Development, Aging, and Neurodegenerative Disease; 5 The Ubiquitin-Proteasome System in Neurodegenerative Diseases: More than the Usual Suspects6 Regulation of the Polyglutamine Androgen Receptor by the Hsp90/Hsp70-Based Chaperone Machinery7 Amyloid Remodeling by Hsp104; 8 Chaperone-Dependent Amyloid Assembly and Prion Toxicity; 9 Modulation of Amyloid Propagation in Yeast by Hsp70 and its Regulators and Chaperone Partners; 10 ALS and the Copper Chaperone CCS; 11 Emerging Area: TorsinA, a Novel ATP-Dependent Factor Linked to Dystonia; 12 Therapeutics: Harnessing the Power of Molecular and Pharmacological Chaperones; IndexHow protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperoneWiley series in protein and peptide science.Molecular chaperonesNervous systemDegenerationMolecular chaperones.Nervous systemDegeneration.612.8Witt Stephan N927568MiAaPQMiAaPQMiAaPQBOOK9910139612003321Protein chaperones and protection from neurodegenerative diseases2084000UNINA