04716nam 2200697Ia 450 991013961180332120200520144314.01-283-25776-997866132577651-118-06758-41-118-06759-21-118-06752-5(CKB)2550000000043383(EBL)693185(OCoLC)746324265(SSID)ssj0000539765(PQKBManifestationID)11357057(PQKBTitleCode)TC0000539765(PQKBWorkID)10571011(PQKB)10249447(MiAaPQ)EBC693185(Au-PeEL)EBL693185(CaPaEBR)ebr10510394(CaONFJC)MIL325776(PPN)243332866(EXLCZ)99255000000004338320110121d2011 uy 0engurcn|||||||||txtccrOral bioavailability[electronic resource] basic principles, advanced concepts, and applications /edited by Ming Hu, Xiaoling LiHoboken, NJ John Wiley & Sonsc20111 online resource (570 p.)Wiley series in drug discovery and developmentDescription based upon print version of record.0-470-26099-8 Includes bibliographical references.ORAL BIOAVAILABILITY; CONTENTS; Foreword; Preface; Contributors; 1 Barriers to Oral Bioavailability-An Overview; 2 Physicochemical Characterization of Pharmaceutical Solids; 3 Solubility of Pharmaceutical Solids; 4 In Vitro Dissolution of Pharmaceutical Solids; 5 Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption; 6 Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways; 7 In Vitro-In Vivo Correlations of Pharmaceutical Dosage Forms; 8 Drug Metabolism in Gastrointestinal Tract9 Efflux of Drugs via Transporters-The Antiabsorption Pathway 10 Liver Drug Metabolism; 11 Protein Binding of Drugs; 12 Urinary Excretion of Drugs and Drug Reabsorption; 13 Pharmacokinetic Behaviors of Orally Administered Drugs; 14 Effects of Food on Drug Absorption; 15 Drug-Drug Interactions and Drug-Dietary Chemical Interactions; 16 Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans; 17 Amino Acid Drug Transporters; 18 Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide-Based Pharmaceuticals19 Organic Anion and Cation Drug Transporters 20 Gastric Retentive Drug Delivery Systems; 21 Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems; 22 Prodrug Strategies to Enhance Oral Drug Absorption; 23 Oral Delivery of Protein/Peptide Therapeutics; 24 ABC Transporters in Intestinal and Liver Efflux; 25 Interplay Between Efflux Transporters and Metabolic Enzymes; 26 Regulatory Considerations in Metabolism- and Transporter-Based Drug Interactions; 27 Caco-2 Cell Culture Model for Oral Drug Absorption; 28 MDCK Cells and Other Cell-Culture Models of Oral Drug Absorption29 Intestinal Perfusion Methods for Oral Drug Absorptions 30 Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion; 31 In vivo Methods for Oral Bioavailability Studies; 32 Determination of Regulation of Drug-Metabolizing Enzymes and Transporters; 33 Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction; IndexUnderstand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the aWiley series in drug discovery and development.DrugsBioavailabilityDrug developmentIntestinal absorptionDrugsBioavailability.Drug development.Intestinal absorption.615/.19Hu MingPh. D.883616Li Xiaoling1957-505392MiAaPQMiAaPQMiAaPQBOOK9910139611803321Oral bioavailability1973599UNINA