06613nam 22011293u 450 991013959640332120230725051155.01-283-23945-097866132394570-470-93995-80-470-93994-X(CKB)2550000000046148(EBL)697477(OCoLC)748937811(SSID)ssj0000536955(PQKBManifestationID)12231342(PQKBTitleCode)TC0000536955(PQKBWorkID)10565046(PQKB)11732087(MiAaPQ)EBC697477(EXLCZ)99255000000004614820131014d2011|||| u|| |engur|n|---|||||txtccrFundamental Neuropathology for Pathologists and Toxicologists[electronic resource] Principles and TechniquesHoboken Wiley20111 online resource (644 p.)Description based upon print version of record.0-470-22733-8 Fundamental Neuropathology for Pathologists and Toxicologists: Principles and Techniques; CONTENTS; CONTRIBUTORS; FOREWORD; PREFACE; INTRODUCTION; PART 1: FUNDAMENTALS OF NEUROBIOLOGY; 1 Fundamental Neuropathology for Pathologists and Toxicologists: An Introduction; 2 Functional Neuroanatomy; 3 Atlas of Comparative Neuroanatomy; 4 Principles of Comparative and Correlative Neurodevelopment and Their Implications for Developmental Neurotoxicity; 5 Localizing Neuropathological Lesions Using Neurological Findings; 6 Behavioral Model Systems for Evaluating Neuropathology7 Cognitive Assessments in Nonhuman Primates8 Impact of Aging on Brain Structure and Function in Rodents and Canines; 9 Fundamentals of Neurotoxicity Detection; PART 2: TOXICOLOGIC NEUROPATHOLOGY: METHODOLOGY; 10 Practical Neuropathology of the Rat and Other Species; 11 Fluoro-Jade Dyes: Fluorochromes for the Histochemical Localization of Degenerating Neurons; 12 Histological Markers of Neurotoxicity (Nonfluorescent); 13 Common Histological Artifacts in Nervous System Tissues; 14 High-Definition Microscopic Analysis of the Nervous System15 Stereological Solutions for Common Quantitative Endpoints in Neurotoxicology16 Anatomy and Processing of Peripheral Nerve Tissues; 17 Pathology Methods in Nonclinical Neurotoxicity Studies: Evaluation of Muscle; 18 In Vivo Imaging Applications for the Nervous System in Animal Models; 19 Cerebrospinal Fluid Analysis in Toxicological Neuropathology; 20 Molecular Techniques in Toxicological Neuropathology; PART 3: TOXICOLOGICAL NEUROPATHOLOGY: CURRENT PRACTICES; 21 Evaluation of the Adult Nervous System in Preclinical Studies22 Pathology Methods in Nonclinical Neurotoxicity Studies: The Developing Central Nervous System23 Neuropathological Analysis of the Peripheral Nervous System; 24 Toxicological Pathology of the Retina and Optic Nerve; 25 Toxicological Neuropathology of the Ear; 26 Neuropathology of the Olfactory System; PART 4: APPLIED TOXICOLOGICAL NEUROPATHOLOGY; 27 Spinal Delivery and Assessment of Drug Safety; 28 Diagnostic Neuropathology; 29 Toxicological Neuropathology in Medical Practice; 30 Toxicological Neuropathology in Veterinary Practice31 Regulatory Considerations in Toxicological Neuropathology32 The Neuropathology Report and the Neuropathology Peer Review Report; 33 Preparation of Personnel for Performing Neuropathological Assessment; 34 Regulatory Guide to the Histopathological Assessment of Neurotoxicity Studies; 35 Toxicological Neuropathology: The Next Two Decades; APPENDIXES: READY REFERENCES OF NEUROBIOLOGY KNOWLEDGE; Appendix 1: Neural Cell Markers of Potential Utility for Toxicological Neuropathology Applications; Appendix 2: Text-Based Neuroanatomic Atlases for Toxicological Neuropathology StudiesAppendix 3: Text-Based Neurobiology References for Toxicological NeuropathologistsThis book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology - including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).Models, AnimalNervous system -- DiseasesNeurotoxicity Syndromes -- diagnosisNeurotoxicity Syndromes -- physiopathologyNeurotoxicologyNeurotoxicologyDiseasesNervous systemInvestigative TechniquesPoisoningAnatomyNoxaeNervous System DiseasesSubstance-Related DisordersDiseasesToxic ActionsChemical Actions and UsesNeurotoxicity SyndromesDiagnosisNeurotoxinsNervous SystemModels, AnimalMedicineHILCCHealth & Biological SciencesHILCCNeurologyHILCCModels, Animal.Nervous system -- Diseases.Neurotoxicity Syndromes -- diagnosis.Neurotoxicity Syndromes -- physiopathology.Neurotoxicology.NeurotoxicologyDiseasesNervous systemInvestigative TechniquesPoisoningAnatomyNoxaeNervous System DiseasesSubstance-Related DisordersDiseasesToxic ActionsChemical Actions and UsesNeurotoxicity SyndromesDiagnosisNeurotoxinsNervous SystemModels, AnimalMedicineHealth & Biological SciencesNeurology616.8071Bolon Brad970645Butt Mark970646AU-PeELAU-PeELAU-PeELBOOK9910139596403321Fundamental Neuropathology for Pathologists and Toxicologists2206211UNINA